C. Forray

Publications87
h-index31
Citations3,663
Highly Influential Citations160
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Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF*
TLDR
The localization of mRNA and binding sites of these receptors in the dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei supports a role for NPFF in pain modulation and suggests a potential role forNPFF1 in feeding.
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Nature Med. 8, 825–830 (2002). Bharat Lagu was omitted from the list of authors. The correct list is below. B. Borowsky, M.M. Durkin, K. Ogozalek, M.R. Marzabadi, J. DeLeon, B. Lagu, R. Heurich, H.…
Expression Cloning of a Rat Hypothalamic Galanin Receptor Coupled to Phosphoinositide Turnover*
TLDR
Activation of GALR2 receptors with porcine Galanin and other galanin analogues increased inositol phospholipid turnover and intracellular calcium levels in stably transfected Chinese hamster ovary cells and generated calcium-activated chloride currents in Xenopus oocytes, suggesting that the rat GALr2 receptor is primarily coupled to the activation of phospholIPase C.
Identification and Characterization of Two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System*
TLDR
Two structurally related, G-protein-coupled receptors were identified as receptors for the neuropeptide, neuromedin U, which is found in highest levels in the gut and genitourinary system but is also expressed in the spinal cord and discrete regions of the brain.
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
TLDR
SNAP-7941, a selective, high-affinity MCH1 receptor (MCH1-R) antagonist, inhibited food intake stimulated by central administration of MCH, reduced consumption of palatable food, and, after chronic administration to rats with diet-induced obesity, resulted in a marked, sustained decrease in body weight.
Qualify: a randomized head-to-head study of aripiprazole once-monthly and paliperidone palmitate in the treatment of schizophrenia
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.
TLDR
The findings of the present study suggest that selective alpha 1c-adrenergic receptor antagonists may be clinically more efficacious and better tolerated agents for the treatment of symptomatic benign prostatic hyperplasia.
5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder
TLDR
A significant difference in the rs7997012 allele frequency between resistant and nonresistant patients is found, but following the Bonferroni correction it could not find any association between this single nucleotide polymorphism and treatment resistance phenotype.
Modeling and mutagenesis of the human alpha 1a-adrenoceptor: orientation and function of transmembrane helix V sidechains.
TLDR
A specific rotational orientation of TM V is proposed as part of a revised receptor model, which also takes into account more recently reported information about the structure of rhodopsin, and accounts for direct interactions which are proposed between Ser 188 and Ser 192 and the meta and para hydroxyl groups of norepinephrine in the G-protein coupled receptor state.
4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.
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