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Y chromosome microdeletions and alterations of spermatogenesis.
A clear correlation exists between the size and localization of the deletions and the testicular phenotype, however, it is clear that larger deletions are associated with the most severe testicular damage.
Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function.
- M. Rossato, F. Ion Popa, M. Ferigo, G. Clari, C. Foresta
- Biology, ChemistryThe Journal of clinical endocrinology and…
- 1 February 2005
It is demonstrated that human sperm express the CB(1), but not CB(2), cannabinoid receptor (CB-R) subtype located in the head and middle piece of the sperm, which negatively influences important sperm functions and suggests a possible role for the cannabinoid system in the pathogenesis of some forms of male infertility.
Male infertility: role of genetic background.
Molecular and cellular endocrinology
Role of hormones, genes, and environment in human cryptorchidism.
Environmental factors acting as endocrine disruptors of testicular descent might also contribute to the etiology of cryptorchidism and its increased incidence in recent years.
Association of partial AZFc region deletions with spermatogenic impairment and male infertility
Data show that, beside complete AZFc deletions, specific partial deletions represent a risk factor for male infertility, even if with different effect on spermatogenesis, as well as suggesting that the contribution of the different deletions to male infertility varies.
Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy.
- A. Ferlin, B. Arredi, C. Foresta
- Biology, MedicineThe Journal of clinical endocrinology and…
- 1 March 2007
This extensive clinical research expands the knowledge on genotype-phenotype relationships and confirms that the identification of Yq microdeletions has significant diagnostic and prognostic value, adding useful information for genetic counseling in these patients.
High-power microscopy for selecting spermatozoa for ICSI by physiological status.
Androgen receptor gene CAG and GGC repeat lengths in idiopathic male infertility.
- A. Ferlin, L. Bartoloni, G. Rizzo, A. Roverato, A. Garolla, C. Foresta
- BiologyMolecular human reproduction
- 1 June 2004
A combined effect of CAG and GGC repeat numbers on AR function and the first evidence of a relationship of particular CAG/GGC haplotypes with male infertility are shown.
Human male infertility and Y chromosome deletions: role of the AZF-candidate genes DAZ, RBM and DFFRY.
Yq microdeletions are analysed to suggest that larger deletions involving more than one AZF-candidate gene are associated with a more severe testicular phenotype, and the DFFRY gene was absent in a fraction of patients, making it a candidate AZFa gene.