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A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis
Sepsis is a deadly disease characterized by the inability to regulate the inflammatory–coagulation response in which the endothelium plays a key role. The cause of this perturbation remains poorlyExpand
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Matrix Metalloprotease-1a Promotes Tumorigenesis and Metastasis*
Background: Mmp1a is the postulated mouse genetic homologue of MMP1, but its functions in cancer are unknown. Results: Endogenous Mmp1a promotes invasion, tumorigenesis, and metastasis of lung cancerExpand
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Targeting protease-activated receptor-1 with cell-penetrating pepducins in lung cancer.
Protease-activated receptors (PARs) are G-protein-coupled receptors that are activated by proteolytic cleavage and generation of a tethered ligand. High PAR1 expression has been documented in aExpand
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Mouse Matrix Metalloprotease‐1a (Mmp1a) Gives New Insight Into MMP Function
Matrix metalloprotease‐1 (MMP1) has been implicated in many human disease processes, however the lack of a well characterized murine homologue has significantly limited the study of MMP1 and theExpand
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A Twenty-Sixth Amendment Challenge to State Voter ID Laws
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Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis
Matrix metalloprotease-1 (MMP1) is an important mediator of tumorigenesis, inflammation and tissue remodeling through its ability to degrade critical matrix components. Recent studies indicate thatExpand
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Clozapine-induced acute gastrointestinal necrosis: a case report
BackgroundClozapine is known to cause fecal impaction and ileus with resultant colonic necrosis due to compression of colonic mucosa. There are rare reports of clozapine causing necrosis of otherExpand
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Digital compression of facial arteries facilitates cutaneous nasal surgery
in vitro and in vivo studies suggests that Treg cells can suppress the activities of CD4+ and CD8+ lymphocytes. Cox et al. assessed lymphocyte homeostasis following alemtuzumab treatment in MS. TheyExpand
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Article the President and the Detainees
  • Aziz Huq, Mao, +23 authors Matt Waxman Workshop
and present research professionals at the Coase-Sandor Institute for Law and Economics—for their extensive help with preparing and analyzing data for this Article; Joey Burton, the Institute's formerExpand
Combating Neonatal Mortality in Rural Haiti—Early Assessment of “Helping Babies Breathe” in a Community Setting [27Q]
INTRODUCTION: Community Health Initiative Haiti (CHI), a non-profit organization working in rural Haiti, has witnessed high rates of infant mortality. In response, CHI adopted the Helping BabiesExpand