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Mendelian randomization of blood lipids for coronary heart disease
TLDR
The genetic findings support a causal effect of triglycerides on CHD risk, but a causal role for HDL-C, though possible, remains less certain. Expand
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data
TLDR
Reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health, and individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. Expand
A genome-wide association study of anorexia nervosa
TLDR
The accrual of large genotyped AN case-control samples should be an immediate priority for the field, suggesting that true findings exist but the sample, the largest yet reported, was underpowered for their detection. Expand
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits
TLDR
This work applied a hybrid whole-genome sequencing (WGS) and deep imputation approach to examine the broader allelic architecture of 12 anthropometric traits associated with height, body mass, and fat distribution in up to 267,616 individuals to report 106 genome-wide significant signals that have not been previously identified. Expand
Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis
TLDR
Conventional and multivariate Mendelian randomisation analysis implicates a causal role for urate in the development of coronary heart disease, but these estimates might be inflated by hidden pleiotropy. Expand
Genetic Variants at Chromosome 9p21 and Risk of First Versus Subsequent Coronary Heart Disease Events
TLDR
Ch9p21 shows differential association with risk of first versus subsequent coronary heart disease (CHD) events through systematic review and meta-analysis, which has implications for genetic risk prediction in patients with established CHD and for mechanistic understanding of how Ch 9p21 influences risk of CHD. Expand
The druggable genome and support for target identification and validation in drug development
TLDR
This work connected complex disease- and biomarker-associated loci from genome-wide association studies to an updated set of genes encoding druggable human proteins, to agents with bioactivity against these targets, and, where there were licensed drugs, to clinical indications. Expand
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
TLDR
Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. Expand
HLA class II locus and susceptibility to podoconiosis.
BACKGROUND Podoconiosis is a tropical lymphedema resulting from long-term barefoot exposure to red-clay soil derived from volcanic rock. The World Health Organization recently designated it as aExpand
Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis
TLDR
Taller individuals have a lower risk of CHD with potential explanations being that taller people have a better lung function and lower levels of body mass index, cholesterol and blood pressure. Expand
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