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Molecular and Functional Analyses of a Human Parvovirus B19 Infectious Clone Demonstrates Essential Roles for NS1, VP1, and the 11-Kilodalton Protein in Virus Replication and Infectivity
- N. Zhi, Ian P Mills, Jun Lu, Susan Wong, C. Filippone, K. Brown
- BiologyJournal of Virology
- 15 June 2006
A previously unrecognized role for the 11-kDa protein is suggested, which was critical for VP2 capsid production and trafficking in infected cells and enhances the understanding of the key features of the B19 viral genome and proteins.
Ex Vivo-Generated CD36+ Erythroid Progenitors Are Highly Permissive to Human Parvovirus B19 Replication
This is the first description of an ex vivo method to produce large numbers of EPCs that are highly permissive to B19V infection and replication, offering a cellular system that mimics in vivo infection with this pathogenic human virus.
A Severe Bite From a Nonhuman Primate Is a Major Risk Factor for HTLV-1 Infection in Hunters From Central Africa.
- C. Filippone, E. Betsem, A. Gessain
- Biology, MedicineClinical infectious diseases : an official…
- 1 June 2015
These results strongly suggest ongoing direct zoonotic acquisition of STLV-1 in humans through severe NHP bites during hunting activities, and link to bite severity.
Genetic variability and integration of Merkel cell polyomavirus in Merkel cell carcinoma.
VP1u phospholipase activity is critical for infectivity of full-length parvovirus B19 genomic clones.
Parvovirus B19 genome as a single, two-state replicative and transcriptional unit.
Functional analysis and quantitative determination of the expression profile of human parvovirus B19.
Molecular Epidemiology of Merkel Cell Polyomavirus: Evidence for Geographically Related Variant Genotypes
Phylogenetic analyses demonstrate the existence of 5 major geographically related MCPyV genotypes (Europe/North America, Africa [sub-Saharan], Oceania, South America, and Asia/Japan).
Zoonotic Transmission of Two New Strains of Human T-lymphotropic Virus Type 4 in Hunters Bitten by a Gorilla in Central Africa.
- L. Richard, A. Mouinga-Ondémé, A. Gessain
- BiologyClinical infectious diseases : an official…
- 15 September 2016
Molecular screening of 300 at-risk people from Central Africa identified 2 human T-lymphotropic virus (HTLV)-4-infected individuals, one of which was highly divergent and was designated as the HTLV-4 subtype-b prototype.
Erythroid Progenitor Cells Expanded from Peripheral Blood without Mobilization or Preselection: Molecular Characteristics and Functional Competence
This approach yielding EPC directly from unmanipulated peripheral blood is gratifyingly robust and will facilitate the study of myeloid infectious agents such as the B19 virus, as well as the examination of erythropoiesis and its cellular and molecular mechanisms.