• Publications
  • Influence
Comparison of tests used to distinguish smokers from nonsmokers.
Questionnaire and biochemical measures of smoking were studied in 211 hospital outpatients. Eleven different tests of smoke intake were compared for their ability to categorize smokers and nonsmokersExpand
  • 960
  • 34
Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers.
Blood nicotine and carboxyhaemoglobin (COHb) concentrations were studied in 330 smokers (206 women and 124 men). Blood nicotine concentrations in individual smokers varied from 25 to 444 nmol/l (4 toExpand
  • 459
  • 22
  • PDF
Discriminative stimulus properties of nicotine: Further evidence for mediation at a cholinergic receptor
Rats were trained to discriminate nicotine (0.4 mg/kg SC) from saline in a standard two-bar operant conditioning procedure with food reinforcement. The response to nicotine was dose-related and atExpand
  • 93
  • 15
Randomised controlled trial of nasal nicotine spray in smoking cessation
Studies with nicotine chewing gum and nicotine skin patches indicate that nicotine replacement can help people to give up smoking. The rapidity with which nicotine is absorbed when given as a nasalExpand
  • 274
  • 14
Cigarette smoking: a dependence on high-nicotine boli.
  • 264
  • 11
Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure.
Cotinine elimination from plasma, saliva, and urine was studied over 11 days in five subjects (three nonsmokers and two occasional smokers). Half-lives for cotinine averaged 16-19 hours in theExpand
  • 275
  • 11
Biochemical markers of smoke absorption and self reported exposure to passive smoking.
One hundred non-smoking patients attending hospital outpatient clinics reported their degree of passive exposure to tobacco smoke over the preceding three days and provided samples of blood, expiredExpand
  • 326
  • 9
  • PDF
Nicotine yield from machine-smoked cigarettes and nicotine intakes in smokers: evidence from a representative population survey.
BACKGROUND The relevance of nicotine yields from machine-smoked cigarettes for quantifying smokers' nicotine intakes and exposure to cigarette toxins has been called into question. However, mostExpand
  • 205
  • 9
  • PDF
Transdermal nicotine for active ulcerative colitis.
BACKGROUND Ulcerative colitis is largely a disease of nonsmokers. Because anecdotal reports suggest that smoking and nicotine may improve the symptoms of the disease, we examined the effect ofExpand
  • 476
  • 8
Passive smoking and risk of coronary heart disease and stroke: prospective study with cotinine measurement
Abstract Objective To examine the associations between a biomarker of overall passive exposure to tobacco smoke (serum cotinine concentration) and risk of coronary heart disease and stroke. DesignExpand
  • 332
  • 8
  • PDF