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Cocoa Reduces Blood Pressure and Insulin Resistance and Improves Endothelium-Dependent Vasodilation in Hypertensives
TLDR
DC decreased BP and serum LDL cholesterol, improved FMD, and ameliorated insulin sensitivity in hypertensives, suggesting that, while balancing total calorie intake, flavanols from cocoa products may provide some cardiovascular benefit if included as part of a healthy diet for patients with EH.
A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients.
Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.
TLDR
FRDC ameliorated insulin sensitivity and beta-cell function, decreased BP, and increased FMD in IGT hypertensive patients, suggesting flavanol-rich, low-energy cocoa food products may have a positive impact on CVD risk factors.
Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons.
TLDR
Dark, but not white, chocolate decreases blood pressure and improves insulin sensitivity in healthy persons and the homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI).
Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the
TLDR
The most relevant methodological issues in the research on endothelial function and dysfunction are summarized in this paper.
Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo.
TLDR
The data show that insulin stimulates both in vitro and in vivo ET-1 secretion, suggesting that such interaction could play a significant role in the development of atherosclerotic lesions in hyperinsulinemic conditions.
Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled
TLDR
This dietary intervention study provides evidence that regular CF consumption can reduce some measures of age-related cognitive dysfunction, possibly through an improvement in insulin sensitivity, and suggests that the habitual intake of flavanols can support healthy cognitive function with age.
Black tea consumption dose-dependently improves flow-mediated dilation in healthy males
TLDR
This study is the first showing black tea ingestion dose dependently improved flow-mediated dilation and decreased peripheral arterial stiffness in healthy volunteers, and suggests that worldwide all tea drinkers could benefit from protective cardiovascular effects exerted by tea.
Comparison of the Captopril and the Saline Infusion Test for Excluding Aldosterone-Producing Adenoma
TLDR
Both the CAPT and the SAL are safe and moderately accurate for excluding APA; at a sodium intake >7.6 g per day, the SAL offers no advantage over the easier-to-perform CAPT.
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