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Resveratrol Is Active against Leishmania amazonensis: In Vitro Effect of Its Association with Amphotericin B
TLDR
The anti-Leishmania effect of resveratrol and its potential synergistic association with AMB indicate that these compounds should be subjected to further studies of drug association therapy in vivo. Expand
Leishmanicidal Effect of Synthetic trans-Resveratrol Analogs
TLDR
Among the analogs tested, piceatannol, which is a metabolite of resveratrol, was the more promising candidate for future studies regarding treatment of leishmaniasis. Expand
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
TLDR
It is found that preventive protocols result in higher treatment success rates and should be avoided during advanced steps of in vivo trials of novel anti-T. Expand
Leishmanicidal effects of piperine, its derivatives, and analogues on Leishmania amazonensis.
TLDR
Piperine and its phenylamide analogue are candidates for development of drugs for cutaneous leishmaniasis treatment, suggesting that they affect different target mechanisms. Expand
Oleanolic acid (OA) as an antileishmanial agent: Biological evaluation and in silico mechanistic insights.
TLDR
In silico studies performed to evaluate OA molecular properties and to elucidate the possible mechanism of action over the Leishmania enzyme sterol 14α-demethylase (CYP51), it is suggested that OA interacts efficiently with CYP51 and could inhibit the ergosterol synthesis pathway. Expand
Increase in fatty acids and flotillins upon resveratrol treatment of human breast cancer cells
TLDR
The polyphenol compound resveratrol was used to alter the structure and function of the plasma membrane to study the relationship between the formation of lipid rafts and the expression of flotillins and lipids in human breast cancer cells and found an increase in fatty acids in MCF-7 and MDA-MB-231 cells upon resver atrol treatment. Expand
Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells
TLDR
It is demonstrated that R-C-P results in cytotoxic effects in MCF-7 cells and that this outcome is associated with decreasing GLO1 activity and mitochondrial dysfunction. Expand
Anti-Leishmania amazonensis activity of Serjania lethalis A. St.-Hil.
TLDR
The evaluations of the IC50 values showed that HF, DDF and MDF decreased NO production in infected macrophages stimulated with IFN-γ and LPS, and HF increased the production of TNF-α in Leishmania infectedmacrophages. Expand
Leishmanicidal activity of the alkaloid-rich fraction from Guatteria latifolia.
TLDR
Evaluated in vitro the anti-Leishmania amazonensis activity of crude extracts of branches, leaves and fruits of Guatteria latifolia and indicated that at the IC50s GCE, GF1 and GF2 decreased NO production of infected macrophages stimulated with IFN-γ and LPS, besides, only GF1 decreased the production of TNF-α. Expand
Anti-Leishmania amazonensis activity of the terpenoid fraction from Eugenia pruniformis leaves.
TLDR
The results showed the antileishmanial activity of E. pruniformis terpenoids and its potential for further studies as a source of new drugs for leishmaniasis. Expand
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