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Clinical spectrum of cryoglobulinaemic neuropathy
Background and objective: Cryoglobulinaemic neuropathy (CN) is probably common, as it is usually related to HCV infection. The aim of this study was to delineate the clinical spectrum of CN in aExpand
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How can elderly apolipoprotein E ε4 carriers remain free from dementia?
Apolipoprotein E (APOE) ε4 is a major risk factor for Alzheimer's disease (AD) and dementia, but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in modifyingExpand
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Cognitive functioning among patients with diabetic foot.
AIMS Using diabetic foot (DF) as an indicator of severe diabetes, we aimed to investigate the cognitive profile of DF patients and the relations between cognitive functioning and both diabetesExpand
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Alzheimer's Disease Progression: Factors Influencing Cognitive Decline.
BACKGROUND Alzheimer's disease (AD) patients present high variability in the rate of cognitive decline. Despite the wide knowledge on factors influencing dementia risk, little is known on whatExpand
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Rethinking on the concept of biomarkers in preclinical Alzheimer’s disease
The neuropathological processes eventually leading to Alzheimer’s disease (AD) are thought to start decades before the appearance of clinical symptoms and the clinical diagnosis of AD dementia. TheExpand
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Imaging and Cognitive Reserve Studies Predict Dementia in Presymptomatic Alzheimer's Disease Subjects
There is strong evidence that Alzheimer's disease (AD) pathology starts decades before clinical onset. Cognitive reserve (CR) and brain reserve can be a good predictive model for AD development.Expand
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Epidemiology of Alzheimer’s Disease
The aging of populations has become a worldwide phenomenon [1]. In 1990, 26 nations had more than two million elderly citizens aged 65 years and older, and the projections indicate that an additionalExpand
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Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functionalExpand
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The diagnosis of dementias: a practical tool not to miss rare causes
Dementia represents one of the most diffuse disorders of our Era. Alzheimer’s disease is the principle cause of dementia worldwide. Metabolic, infectious, autoimmune, inflammatory, and geneticExpand
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Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier.
According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy. We describe a case of dementia clinically compatible withExpand
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