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Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost
This data indicates that reversion to wild type can occur following transmission to MHC-mismatched hosts in the absence of cytotoxic T-lymphocyte (CTL) pressure, due to the reduced fitness of the escape mutant virus.
Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
The identification of this common M. nemestrina MHC class I allele restricting a functionally important immunodominant SIV Gag epitope establishes a basis for studying CD8+ T-cell responses against AIDS in an important, widely available nonhuman primate species.
MAIT cells are depleted early but retain functional cytokine expression in HIV infection
It is found that MAIT cells were depleted early during HIV infection, and although there was a concomitant rise in Vα7.2+CD161– cells, these were MR1 tetramer negative, indicating that these are unlikely to be alteredMAIT cells.
The pigtail macaque MHC class I allele Mane‐A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion
Two technologies for the detection of Mane‐A*10 in outbred pigtail macaques were developed: reference strand‐mediated conformational analysis and sequence‐specific primer polymerase chain reaction, and mutational escape at KP9 following acute SIV infection are demonstrated.
Reversion of immune escape HIV variants upon transmission: insights into effective viral immunity.
Peripheral NKT Cells in Simian Immunodeficiency Virus-Infected Macaques
- C. Fernandez, A. C. Chan, K. Kyparissoudis, R. De Rose, D. Godfrey, S. Kent
- BiologyJournal of Virology
- 3 December 2008
The results demonstrate the infection-driven depletion of peripheral CD4+ NKT cells during both SHIV and SIV infection of macaques, and the depletion was tightly correlated with the depletion of total CD4- T cells.
Control of Viremia and Prevention of AIDS following Immunotherapy of SIV-Infected Macaques with Peptide-Pulsed Blood
High-level, SIV-specific CD4 and CD8 T-cell immunity was induced following immunization, both during antiretroviral cover and without, and a significant delay in AIDS-related mortality resulted.
Natural Host Genetic Resistance to Lentiviral CNS Disease: A Neuroprotective MHC Class I Allele in SIV-Infected Macaques
Human immunodeficiency virus (HIV) infection frequently causes neurologic disease even with anti-retroviral treatment. Although associations between MHC class I alleles and acquired immunodeficiency…
Serial study of lymph node cell subsets using fine needle aspiration in pigtail macaques.