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Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship
TLDR
TIC coexists with all forms of pelvic serous carcinoma and is a plausible origin for many of these tumors, although further studies are needed to elucidate the etiologic significance. Expand
The Immune Landscape of Cancer
TLDR
An extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA identifies six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis. Expand
Comprehensive Characterization of Cancer Driver Genes and Mutations
TLDR
This study reports a PanCancer and PanSoftware analysis spanning 9,423 tumor exomes (comprising all 33 of The Cancer Genome Atlas projects) and using 26 computational tools to catalog driver genes and mutations, identifying 299 driver genes with implications regarding their anatomical sites and cancer/cell types. Expand
The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome
TLDR
The fimbria was the most common location for early serous carcinoma in this series of BRCA-positive women, and Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarianSerous carcinomas. Expand
Oncogenic Signaling Pathways in The Cancer Genome Atlas
TLDR
This work charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Expand
Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction.
TLDR
The distal fallopian tube seems to be the dominant site of origin for early malignancies detected in approximately 6% of women undergoing ovarian cancer risk-reduction surgery, and the greatest proportion of serous cancer risk in BRCA mutation-positive women should be assigned to the fimbria rather than the ovary. Expand
Osteopontin as a potential diagnostic biomarker for ovarian cancer.
TLDR
The findings provide evidence for an association between levels of a biomarker, osteopontin, and ovarian cancer and suggest that future research assessing its clinical usefulness would be worthwhile. Expand
Pathogenic Germline Variants in 10,389 Adult Cancers
TLDR
The largest investigation of predisposition variants in cancer to date finds 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types, informing future guidelines of variant classification and germline genetic testing in cancer. Expand
Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center.
TLDR
High mitotic index appears to be an adverse prognostic indicator for recurrence in patients with placental site trophoblastic tumors reviewed from 1982-1999 in an effort to identify prognostic factors for recurrent disease. Expand
Robotic versus open radical hysterectomy: a comparative study at a single institution.
TLDR
Robotic radical hysterectomy results in lower blood loss and shorter length of stay, compared to ORH, and is a promising new surgical technique that deserves further study. Expand
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