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Cell Volume Regulation in Chondrocytes
Chondrocytes are the cells within cartilage which produce and maintain the extracellular matrix. Volume regulation in these cells is vital to their function and occurs in several differentExpand
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PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia
Background: Glucose-sensing neurons are located in several parts of the brain, but are concentrated in the ventromedial nucleus of the hypothalamus (VMH). The importance of these VMH neurons inExpand
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TRPV4 and KCa ion channels functionally couple as osmosensors in the paraventricular nucleus
Transient receptor potential vanilloid type 4 (TRPV4) and calcium‐activated potassium channels (KCa) mediate osmosensing in many tissues. Both TRPV4 and KCa channels are found in the paraventricularExpand
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NK1‐receptor‐expressing paraventricular nucleus neurones modulate daily variation in heart rate and stress‐induced changes in heart rate variability
The paraventricular nucleus of the hypothalamus (PVN) is an established center of cardiovascular control, receiving projections from other nuclei of the hypothalamus such as the dorsomedialExpand
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The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734
Several reports have shown that the periventricular region of the brain, including the paraventricular nucleus (PVN), is critical to sensing and responding to changes in plasma osmolality. FurtherExpand
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Volume Control in the PVN: A Role for TRPV4
The hypothalamus is responsible for maintaining body fluid osmolarity within a narrow range (∼290-300mOsm)[1]. Upon hypotonic challenge, increased heart rate, blood pressure and renal sympatheticExpand
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Ion Channels in the Paraventricular Hypothalamic Nucleus (PVN); Emerging Diversity and Functional Roles
The paraventricular nucleus of the hypothalamus (PVN) is critical for the regulation of homeostatic function. Although also important for endocrine regulation, it has been referred to as theExpand
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Contents Vol. 28, 2011
The role of the paraventricular nucleus of the hypothalamus in the central control of the autonomic nervous system
The paraventricular nucleus (PVN) is a region of the hypothalamus considered the “master controller” of the autonomic nervous system. A subregion of the PVN, the parvocellular subnucleus, is believedExpand