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- Publications
- Influence
Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes.
- D. Morré, R. de Cabo, C. Farley, N. Oberlies, J. L. Mclaughlin
- Biology, Medicine
- Life sciences
- 23 December 1994
Bullatacin, a potential antitumor substance isolated from plants of the Annonaceae, and analogs of bullatacin, known collectively as acetogenins, have been reported previously to show potent activity… Expand
Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers.
- C. Farley, D. F. Dibwe, Jun-ya Ueda, Eric A. Hall, S. Awale, J. Magolan
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 March 2016
A series of functionalized coumarins were synthesized and evaluated for their capacity to inhibit the resistance to starvation of pancreatic cancer cells. This form of cytotoxicity, termed… Expand
Organic Reactions Enabled by Catalytically Active Metal–Metal Bonds
Molecular transition-metal catalysts are predominantly Werner-type coordination complexes, wherein a single metal ion surrounded by ligands functions as the sole locus of reactivity. A major focus of… Expand
Catalytic [5 + 1]-Cycloadditions of Vinylcyclopropanes and Vinylidenes.
- C. Farley, Kohei Sasakura, You-Yun Zhou, Vibha V Kanale, C. Uyeda
- Chemistry, Medicine
- Journal of the American Chemical Society
- 21 February 2020
Polysubstituted cyclohexenes bearing 1,3 (meta) substitution patterns are challenging to access using the Diels-Alder reaction (the ortho-para rule). Here, we report a cobalt-catalyzed reductive [5 +… Expand
Catalytic Reductive Carbene and Vinylidene Transfer Reactions
- C. Farley
- Chemistry
- 29 April 2020
Carbenes are reactive organic intermediates comprised of a neutral, divalent carbon atom. The reactivity of carbenes is often orthogonal to polar functional groups (nucleophiles and electrophiles),… Expand
Composition of N-Acylethanolamines in Physcomitrella Patens at Varying Life Stages
- C. Farley, Aruna Kilaru, +4 authors R. Welti
- Chemistry
- 2016
Catalytic
Cyclooligomerization of Enones with Three
Methylene Equivalents
- C. Farley, You-Yun Zhou, N. Banka, C. Uyeda
- Chemistry, Medicine
- Journal of the American Chemical Society
- 14 September 2018
Cyclic structures are highly represented in organic molecules, motivating a wealth of catalytic methods targeting their synthesis. Among the various ring-forming processes, cyclooligomerization… Expand