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Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes.
Bullatacin, a potential antitumor substance isolated from plants of the Annonaceae, and analogs of bullatacin, known collectively as acetogenins, have been reported previously to show potent activityExpand
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Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers.
A series of functionalized coumarins were synthesized and evaluated for their capacity to inhibit the resistance to starvation of pancreatic cancer cells. This form of cytotoxicity, termedExpand
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Organic Reactions Enabled by Catalytically Active Metal–Metal Bonds
Molecular transition-metal catalysts are predominantly Werner-type coordination complexes, wherein a single metal ion surrounded by ligands functions as the sole locus of reactivity. A major focus ofExpand
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Catalytic [5 + 1]-Cycloadditions of Vinylcyclopropanes and Vinylidenes.
Polysubstituted cyclohexenes bearing 1,3 (meta) substitution patterns are challenging to access using the Diels-Alder reaction (the ortho-para rule). Here, we report a cobalt-catalyzed reductive [5 +Expand
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Catalytic Reductive Carbene and Vinylidene Transfer Reactions
Carbenes are reactive organic intermediates comprised of a neutral, divalent carbon atom. The reactivity of carbenes is often orthogonal to polar functional groups (nucleophiles and electrophiles),Expand
Catalytic Cyclooligomerization of Enones with Three Methylene Equivalents
Cyclic structures are highly represented in organic molecules, motivating a wealth of catalytic methods targeting their synthesis. Among the various ring-forming processes, cyclooligomerizationExpand
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