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Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney and C. elegans.
- E. Holtzman, Sumit Kumar, +7 authors P. Dunham
- Biology, MedicineAmerican journal of physiology. Renal physiology
- 1 October 1998
Hydropathy analyses of the three clones indicate typical KCC topology patterns with 12 trans Membrane segments, large extracellular loops between transmembrane domains 5 and 6 (unique to KCC), and large COOH-terminal domains.
Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase…
- C. Faaland, J. E. Race, G. Ricken, F. Warner, W. J. Williams, E. Holtzman
- Biology, MedicineBiochimica et biophysica acta
- 8 November 1998
These proteins appear to be members of a new family of possible nucleobase transporters with significant sequence similarities with bacterial and Aspergillus nucleobasesTransporters.
Molecular correlates of the action of bis(ethyl)polyamines in breast cancer cell growth inhibition and apoptosis.
- C. Faaland, T. Thomas, +5 authors T. Thomas
- Biology, MedicineBiochemistry and cell biology = Biochimie et…
The authors' studies show growth inhibitory activities of several potentially important analogs on breast cancer cells and indicate that multiple sites are involved in the mechanism of action of these analogs.
Suppression of c-myc oncogene expression by a polyamine-complexed triplex forming oligonucleotide in MCF-7 breast cancer cells.
The data indicate that selective utilization of synthetic polyamines and TFOs might be an important strategy to develop anti-gene-based therapeutic modalities for breast cancer.
Inhibition of epidermal growth factor-stimulated EGF receptor tyrosine kinase activity in A431 human epidermoid carcinoma cells by polyamines.
- C. Faaland, J. Laskin, T. Thomas
- Biology, MedicineCell growth & differentiation : the molecular…
- 1 February 1995
The results suggest that polyamine action in A431 cells involves modulation of EGF receptor signal transduction pathways, and suggests structural specificity of naturally occurring polyamines in this process.
Induction of p21 (CIP1/WAF1/SID1) by estradiol in a breast epithelial cell line transfected with the recombinant estrogen receptor gene:
- T. Thomas, C. Faaland, S. Adhikarakunnathu, L. Watkins, T. Thomas
- Medicine, BiologyBreast Cancer Research and Treatment
A p21-mediated pathway is suggested as a possible mechanism for the growth inhibitory effects of estradiol on at least a subset of ER-transfected cell lines.
Structure-activity relations of s-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells
- T. Thomas, C. Faaland, S. Adhikarakunnathu, T. Thomas
- Biology, MedicineBreast Cancer Research and Treatment
Structural-activity relationships of a series of MGBG derivatives on cell growth, enzyme activities, and polyamine biosynthesis in a hormoneresponsive breast cancer cell line are demonstrated and potential application of SAMDC inhibitors as therapeutic agents are suggested.
Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity.
- C. Faaland, F. Mermelstein, J. Hayashi, J. Laskin
- Biology, MedicineMolecular and cellular biology
- 1 May 1991
It is hypothesized that tyrphostin is not a competitive inhibitor of the EGF receptor tyrosine kinase in intact cells and that it functions by an indirect mechanism.
Effects of epidermal growth factor on MDA‐MB‐468 breast cancer cells: Alterations in polyamine biosynthesis and the expression of p21/CIP1/WAF1
- T. Thomas, S. Balabhadrapathruni, C. Gardner, J. Hong, C. Faaland, T. Thomas
- Biology, MedicineJournal of cellular physiology
- 1 June 1999
The results suggest that the mechanism of growth inhibition by EGF in MDA‐MB‐468 cells include a down‐regulation of polyamine biosynthesis and the induction of p21, an inhibitor of cyclin‐dependent kinases.
Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells.
- T. Thomas, N. Shah, +4 authors T. Thomas
- Biology, MedicineJournal of molecular endocrinology
- 1 April 1999
The results show that multiple proteins associate with ER and that the binding of some of these proteins is highly sensitive to intracellular polyamine concentrations, indicating the importance of the polyamine pathway in the gene regulatory function of estradiol in breast cancer cells.