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In vitro and in vivo anti-inflammatory effects of andrographolide.
Investigating the ability of andrographolide to inhibit the release of inflammatory cytokines in vitro in a model of non-specific inflammation and determining whether such effect can also be exerted in vivo in allergic lung inflammation provide evidence that androg grapholide is an effective anti-inflammatory drug that is active in vitro and in vivo. Expand
Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release
The results show that the A3 receptors on human eosinophils mediate inhibition of both degranulation and O2− release and suggest a therapeutic potential for A3 agonists in diseases such as asthma in which activated eosInophils are involved. Expand
Therapy of bronchial asthma with adenosine receptor agonists or antagonists.
The development of adenosine A(2A)- or (A3)-receptor agonists as antiinflammatory agents or A( 2B-receptor antagonists as inhibitors of mast cell degranulation for the treatment of asthma holds promise. Expand
Low-affinity IgE receptor (FcepsilonRII)-mediated activation of human monocytes by both monomeric IgE and IgE/anti-IgE immune complex.
- C. Ezeamuzie, R. Al-Attiyah, P. Shihab, R. Al-Radwan
- Chemistry, Medicine
- International immunopharmacology
- 1 August 2009
It is shown for the first time, that in CD23-bearing monocytes, IgE sensitization alone can activate monocyte, and that ligation of such IgE by anti-IgE antibody only enhances the response. Expand
Effects of Some Anti-Asthma Drugs on Human Eosinophil Superoxide Anions Release and Degranulation
The results show that some of the anti-asthma drugs, but not all, do exert direct effects on human blood eosinophils but these effects may be stimulus-dependent and by far more pronounced against O–2 release than against degranulation. Expand
Histamine H2 receptors mediate the inhibitory effect of histamine on human eosinophil degranulation
It is suggested that histamine, via stimulation of H2 receptors and a consequent elevation of intracellular levels of cyclic AMP, inhibits human eosinophil degranulation. Expand
Effect of wortmannin on human eosinophil responses in vitro and on bronchial inflammation and airway hyperresponsiveness in Guinea pigs in vivo.
- C. Ezeamuzie, J. Sukumaran, E. Philips
- American journal of respiratory and critical care…
- 1 November 2001
Results show that wortmannin is a potent inhibitor of human eosinophil degranulation and that when administered intranasally can prevent AHR in allergen-challenged guinea pigs, probably by inhibiting eos inophilDegranulation, but not their accumulation in BALF. Expand
Protein kinase C activation inhibits eosinophil degranulation through stimulation of intracellular cAMP production
Results show, for the first time, that in human eosinophils, PMA, via activation of PKCδ isoform, can stimulate cAMP production, and that this may be the basis for its potent anti‐degranulatory effect. Expand
Anti-allergic activity of cyclosporin-A metabolites and their interaction with the parent compound and FK 506.
- C. Ezeamuzie
- Chemistry, Medicine
- International journal of immunopharmacology
- 1 April 1996
Results show that some metabolites of CSA, like the parent compound, possess anti-allergic effects and that at concentrations that are obtainable in transplant patients, synergistic interaction occurs between CSA and its metabolites, and this may be of some therapeutic significance. Expand
Anti-allergic properties of cyclosporin A: inhibition of mediator release from human basophils and rat basophilic leukemia cells (RBL-2H3).
In vitro the immunosuppressive drug cyclosporin A (CS-A) strongly inhibited histamine release from human basophils (HB) and the rat basophilic leukemia cell line (RBL) 2H3 and was compared with the calmodulin inhibitors, W7, TFP and ABCNS; all inhibited Histamine release. Expand