• Publications
  • Influence
The pro-oxidant activity of aluminum.
  • C. Exley
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1 February 2004
TLDR
It is concluded that much, if not all, of the pro-oxidant activity of aluminum might be explained by the formation of an aluminum superoxide semireduced radical ion. Expand
Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease.
TLDR
If the formation of such amyloid is critical to the aetiology of AD then the chelation of Al( III) and Fe(III) may prove to be a protective mechanism whilst the chelorating of Cu(II) and Zn( II) without also chelating Al(III] and Fe (III) might actually exacerbate the condition. Expand
Human exposure to aluminium.
  • C. Exley
  • Environmental Science, Medicine
  • Environmental science. Processes & impacts
  • 25 September 2013
TLDR
The aluminium age is upon us and there is now an urgent need to understand how to live safely and effectively with aluminium. Expand
Silicon in life : A bioinorganic solution to bioorganic essentiality
Abstract The essentiality of silicon in biota is described from the perspective of the interrelationships between geochemistry, biological evolution and biochemistry. A punctuated, as opposed toExpand
The formation of hydroxyaluminosilicates of geochemical and biological significance
Abstract Hydroxyaluminosilicates (HAS) are critical intermediates in the biogeochemical cycles of aluminium and silicon. To understand the extent of their role in controlling the solubility of Al inExpand
Speciation of aluminum in biological systems.
TLDR
Recommendations for further research on Al speciation include determining more accurate Al stability constants with critical low molecular mass ligands such as citrate and phosphate and incorporating more detailed speciation data into future epidemiological studies on the relationship between Al toxicity and various water quality parameters. Expand
A mechanism for acute aluminium toxicity in fish.
TLDR
The mechanism of epithelial cell death is proposed as a general mechanism of aluminium-induced accelerated cell death and is shown to be bipartite. Expand
The cellular toxicity of aluminium.
TLDR
The cellular response to aluminium is found to be biphasic having both stimulatory and inhibitory components and the disruption of second messenger systems is observed and GTPase cycles are potential target sites. Expand
Elevated urinary excretion of aluminium and iron in multiple sclerosis
TLDR
Urinary concentrations of aluminium were significantly increased in RRMS and SPMS such that the levels of aluminium excretion in the former were similar to those observed in individuals undergoing metal chelation therapy, and increased excretion of iron in urine supported a role for iron dysmetabolism in MS. Expand
Slow CCL2-dependent translocation of biopersistent particles from muscle to brain
TLDR
Nanomaterials can be transported by monocyte-lineage cells to DLNs, blood and spleen, and, similarly to HIV, may use CCL2-dependent mechanisms to penetrate the brain. Expand
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