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Structure-Activity Relationships Among a New Class of Antiviral Heterosubstituted 2′,3′-Dideoxynucleoside Analogues
Abstract 3′-Oxa-4′-thiocytidine nucleoside analogues 14–17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found toExpand
Inhibitory activities of herpes simplex viruses type 1 and 2 and human cytomegalovirus by stereoisomers of 2′-deoxy-3′-oxa-5(E)-(2-bromovinyl)uridines and their 4′-thio analogues.
Two series of optically pure 2,4-disubstituted 1,3-dioxolanes and −1,3-oxathiolane nucleosides containing (E)-5-(2-bromovinyl)uracil were synthesized and assayed for activity against HSV-1, HSV-2 andExpand
Expeditious preparation of (−)-2′-deoxy-3′-thiacytidine (3TC)
Abstract The title compound has been prepared in enantiomerically pure form in four steps from (+)-thiolactic acid.
Structure-Activity Relationship of Pyrimidine Heterosubstituted Nucleoside Analogues
Abstract The structure-activity relationship of sixteen 3-deaza, C-4 substituted pyrimidines and imidazo[1,2-c]pyrimidine bases of 1,3-oxathiolanes and 1,3-dioxolanes revealed good anti-HBV activityExpand
Oxidative degradation of L-ascorbic acid acetals to 2′,3′-dideoxy-3′-oxaribofuranosides. Synthesis of enantiomerically pure 2′,3′-dideoxy-3′-oxacytidine stereoisomers as potential antiviral agents
Abstract Enantiomerically pure 2′,3′-dideoxy-3′-oxacytidine nucleoside analogues were synthesized from L-ascorbic acid in eight steps and good overall yield.
Planarians as models of cadmium-induced neoplasia provide measurable benchmarks for mechanistic studies.
It is inferred that neoblast activity does respond to cadmium-induced tumor growth, and that metalloproteinases are required for the progression of cancer in the planarian. Expand
Discovery of imidazo[1,2-c]pyrimidin-5(6H)-one heterosubstituted nucleoside analogues with potent activity against human hepatitis B virus in vitro
Abstract The in vitro antihepatitis B virus (HBV) activities of eleven novel imidazo[1,2-c]pyrimidin-5(6H)-one dideoxynucleoside analogues in which the sugar ring is 1,3-dioxolane or 1,3-oxathiolaneExpand
Decarboxylative Carbon Acylation of Malonates with Aminoacylimidazolides Mediated by Lewis Acids
Abstract Various N-protected aminoacylimidazolides undergo decarboxylative carbon acylation with sodium or potassium nonomethylmalonate in THE in the presence of MgCl2, CoCl2 or MnCl2 to giveExpand
On The Conversion of Arabino- and Ribofuranosyl Methyl Glycosides to Their 1-O-Acetyl Derivatives
Improved conditions for the acetolysis of methyl 2,3,5-tri-O-benzyl-α-and β-L-arabinofuranosides and 2,3,5-tri-O-benzoyl-α-and β-L-ribofuranosides have been investigated. In the case of the arabino...