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Risk factors for progression of brain atrophy in aging
Objectives: To determine the rate of brain atrophy in neurologically asymptomatic elderly and to investigate the impact of baseline variables including conventional cerebrovascular risk factors, APOEExpand
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Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis
In patients with multiple sclerosis (MS), grey matter damage is widespread and might underlie many of the clinical symptoms, especially cognitive impairment. This relation between grey matter damageExpand
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White matter lesion progression, brain atrophy, and cognitive decline: The Austrian stroke prevention study
White matter lesions progress over time, but the clinical consequences are widely unknown. Three‐hundred twenty‐nine elderly community‐dwelling volunteers underwent serial magnetic resonance imagingExpand
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Heterogeneity in age-related white matter changes
White matter changes occur endemically in routine magnetic resonance imaging (MRI) scans of elderly persons. MRI appearance and histopathological correlates of white matter changes are heterogeneous.Expand
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Cognition in multiple sclerosis State of the field and priorities for the future
Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporateExpand
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Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes
Objective: To assess the time course of brain atrophy and the difference across clinical subtypes in multiple sclerosis (MS). Methods: The percent brain volume change (PBVC) was computed on existingExpand
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Cognition in multiple sclerosis
Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporateExpand
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Genome‐wide association studies of cerebral white matter lesion burden
White matter hyperintensities (WMHs) detectable by magnetic resonance imaging are part of the spectrum of vascular injury associated with aging of the brain and are thought to reflect ischemic damageExpand
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Metabolic Syndrome, Brain Magnetic Resonance Imaging, and Cognition
OBJECTIVE We explored cognitive impairment in metabolic syndrome in relation to brain magnetic resonance imaging (MRI) findings. RESEARCH DESIGN AND METHODS We studied 819 participants free ofExpand
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Visual Rating of Age-Related White Matter Changes on Magnetic Resonance Imaging: Scale Comparison, Interrater Agreement, and Correlations With Quantitative Measurements
Background and Purpose— To provide further insight into the MRI assessment of age-related white matter changes (ARWMCs) with visual rating scales, 3 raters with different levels of experience testedExpand
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