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Extracellular Vesicles as New Players in Cellular Senescence
Cell senescence is associated with the secretion of many factors, the so-called “senescence-associated secretory phenotype”, which may alter tissue microenvironment, stimulating the organism to cleanExpand
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Signaling Pathways in Exosomes Biogenesis, Secretion and Fate
Exosomes are small extracellular vesicles (30–100 nm) derived from the endosomal system, which have raised considerable interest in the last decade. Several studies have shown that they mediateExpand
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A distinct beta-hexosaminidase isoenzyme separated from human leukemic lymphocytes and myelocytes.
The beta-hexosaminidase (EC isoenzymes were separated on the basis of their carbohydrate moieties by an affinity chromatography using immobilized phenylboronate. Normal lymphocytes andExpand
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Exosome-based strategies for Diagnosis and Therapy.
Exosomes are small extracellular vesicles (30-120 nm) of endosomal origin, which are gaining the attention of the scientific community. Originally considered only a waste disposal system, they areExpand
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Identification of plasma membrane associated mature β‐hexosaminidase A, active towards GM2 ganglioside, in human fibroblasts
Mature β‐hexosaminidase A has been found associated to the external leaflet of plasma membrane of cultured fibroblasts. The plasma membrane association of β‐hexosaminidase A has been directlyExpand
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Cathepsin D expression is decreased in Alzheimer's disease fibroblasts
Cathepsin D (CTSD), a protease detectable in different cell types whose primary function is to degrade proteins by bulk proteolysis in lysosomes, has been suggested to be involved in Alzheimer'sExpand
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Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques
Innovative label-free microspectroscopy, which can simultaneously collect Brillouin and Raman signals, is used to characterize the viscoelastic properties and chemical composition of living cellsExpand
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Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection
Globally, nearly 2 billion people are infected with the intracellular protozoan Toxoplasma gondii1. This persistent infection can cause severe disease in immunocompromised people and isExpand
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Absence of Metabolic Cross-correction in Tay-Sachs Cells
We have investigated the ability of a receptor-mediated gene transfer strategy (cross-correction) to restore ganglioside metabolism in fibroblasts from Tay-Sachs (TS) patientsin vitro. TS disease isExpand
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Differences in Extracellular Matrix Production and Basic Fibroblast Growth Factor Response in Skin Fibroblasts from Sporadic and Familial Alzheimer’s Disease
Extracellular matrix (ECM) molecules and growth factors, such as fibroblast growth factor (FGF), play a crucial role in Alzheimer’s disease (AD). The purpose of this investigation was to determineExpand
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