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Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite.
Man appears to be relatively resistant to the hepatotoxic effects of paracetamol, and the results in hepatocytes were confirmed by both in vitro and in vivo analyses. Expand
Evidence for a direct role of intracellular calcium in paracetamol toxicity.
Loading of freshly isolated hamster hepatocytes with the Ca2+ specific chelator Quin 2 provided significant protection against the loss of viability caused by paracetamol, and it is concluded that alterations of cytosolic Ca2+. Expand
Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine.
The effects of quinidine at a dose of only 50 mg, on the metabolism of a new drug in EM subjects may prove a useful method of assessing the contribution of the debrisoquine 4-hydroxylase isozyme to the elimination of the drug tested. Expand
Bufuralol 1'-hydroxylase activity of the rat. Strain differences and the effects of inhibitors.
The kinetics of bufuralol 1'-hydroxylase activity of hepatic microsomal fractions have been determined in female DA and Fischer 344 rats, strains between which there is a large difference inExpand
Comparative activation of paracetamol in the rat, mouse and man.
The present study was conducted to investigate some of the possible causes of inter- and intraspecies differences in paracetamol activation and to attempt to identify the specific forms of cytochrome P450 involved. Expand
Effects of nortriptyline on the activities of human and rat liver microsome bufuralol 1'-hydroxylase in vitro.
The results indicate that nortriptyline is a very potent competitive inhibitor to bufuralol 1'-hydroxylase in man and Wistar rat. Expand
Quinidine andtheidentification ofdrugs whoseelimination is impaired insubjects classified aspoormetabolizers ofdebriso- quine
Quinidine anditsdiastereoisomer quinine weretested invitro fortheir effect onthe4hydroxylation ofdebrisoquine, theO-deethylation ofphenacetin andthel'-hydroxylation ofbufuralol, byhumanliverExpand