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Esophageal IgG4 levels correlate with histopathologic and transcriptomic features in eosinophilic esophagitis
Recent data associate eosinophilic esophagitis (EoE) with IgG4 rather than IgE, but its significance and function have not been determined. Our aims were to measure esophageal IgG4 levels and toExpand
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Pediatric Hypereosinophilia: Characteristics, Clinical Manifestations, and Diagnoses.
BACKGROUND Eosinophilia is associated with various conditions, including allergic, infectious, and neoplastic disorders. The diagnostic differential is broad, and data on hypereosinophilia inExpand
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Prevalence of eosinophilic colitis and the diagnoses associated with colonic eosinophilia.
Pediatric eosinophilic colitis (EC) is a rare disease with a prevalence of ∼1/63,000 individuals, and at our tertiary care pediatric medical center, only 2% of patients with the ICD-9/10 code for ECExpand
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Prenatal and perinatal history in Kabuki Syndrome
Kabuki syndrome (KS) is a disorder of epigenetic dysregulation due to heterozygous mutations in KMT2D or KDM6A, genes encoding a lysine‐specific methyltransferase or demethylase, respectively. TheExpand
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How I Do It: Approach to Eosinophilia Presenting with Pulmonary Symptoms.
Eosinophilia with pulmonary involvement is characterized by the presence of peripheral blood eosinophilia, typically ≥500 cells/mm3; pulmonary symptoms and physical exam findings, which areExpand