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The Synthetic Amphipathic Peptidomimetic LTX109 Is a Potent Fungicide That Disturbs Plasma Membrane Integrity in a Sphingolipid Dependent Manner
TLDR
It is found that LTX109 was an efficient fungicide that killed all viable cells in an exponentially growing population as well as a large proportion of cells in biofilm formed on an abiotic surface.
Formation of Extrachromosomal Circular DNA from Long Terminal Repeats of Retrotransposons in Saccharomyces cerevisiae
TLDR
Recombination junctions are detected that are consistent with yeast Ty eccDNAs being generated through recombination events within the genome, opening the possibility that retrotransposable elements could move around in the genome without an RNA intermediate directly through DNA circularization.
Antifungal properties of peptidomimetics with an arginine-[β-(2,5,7-tri-tert-butylindol-3-yl)alanine]-arginine motif against Saccharomyces cerevisiae and Zygosaccharomyces bailii.
TLDR
An array of peptidomimetics based on the arginine-β-(2,5,7-tri-tert-butylindol-3-yl) alanine-arginine (R-Tbt-R) motif was investigated for antifungal and hemolytic activity, and four compounds may have potential as leads for novel preservatives.
Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae
TLDR
DNA circles can offer a flexible adaptive solution but cells lose genetic heterogeneity from circular DNA as they undergo replicative aging, as well as intermediates in chromosomal amplifications.
Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae
TLDR
The heterogeneity of circular DNA offers flexibility in adaptation, but this heterogeneity is remarkably diminished with age, suggesting circular DNAs are intermediates in chromosome amplifications.