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Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins
The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioningExpand
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Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease. These cells could in turn be used forExpand
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GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle.
For survival, embryonic motoneurons in vertebrates depend on as yet undefined neurotrophic factors present in the limb bud. Members of the neurotrophin family are currently the best candidates forExpand
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Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin
A novel neurotrophic factor named Persephin that is approximately 40% identical to glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) has been identified using degenerate PCR.Expand
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Programmed Cell Death of Embryonic Motoneurons Triggered through the FAS Death Receptor
About 50% of spinal motoneurons undergo programmed cell death (PCD) after target contact, but little is known about how this process is initiated. Embryonic motoneurons coexpress the death receptorExpand
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A functionally characterized test set of human induced pluripotent stem cells
Human induced pluripotent stem cells (iPSCs) present exciting opportunities for studying development and for in vitro disease modeling. However, reported variability in the behavior of iPSCs hasExpand
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Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells
Human pluripotent stem cells are a promising source of differentiated cells for developmental studies, cell transplantation, disease modeling, and drug testing. However, their widespread use even forExpand
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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
Mutations in Cu/Zn superoxide dismutase (encoded by SOD1), one of the causes of familial amyotrophic lateral sclerosis (ALS), lead to progressive death of motoneurons through a gain-of-functionExpand
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Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway
Cytokines that are related to ciliary neurotrophic factor (CNTF) are physiologically important survival factors for motoneurons, but the mechanisms by which they prevent neuronal cell death remainExpand
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Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL.
The reasons for the cellular specificity and slow progression of motoneuron diseases such as ALS are still poorly understood. We previously described a motoneuron-specific cell death pathwayExpand
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