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Protein engineering and preclinical development of a GM‐CSF receptor antibody for the treatment of rheumatoid arthritis
- R. Minter, E. S. Cohen, +17 authors M. Sleeman
- Biology, Medicine
- British journal of pharmacology
- 1 January 2013
For antibody therapies against receptor targets, in vivo outcomes can be difficult to predict because of target‐mediated clearance or antigen ‘sink’ effects. The purpose of this work was to engineer… Expand
Healthcare professionals' attitudes toward cancer precision medicine: A systematic review.
Use of precision medicine in oncology is burgeoning and can provide patients with new treatment options. However, it is not clear how precision medicine is impacting healthcare professionals (HCPs),… Expand
Design of a Full-Scale Impact System for Analysis of Vehicle Pedestrian Collisions
The complexity of vehicle-pedestrian collisions necessitates extensive validation of pedestrian computational models. While body components can be individually simulated, overall validation of human… Expand
Experimental Investigation of the Response of the Human Lower Limb to the Pedestrian Impact Loading Environment
Three limbs were taken from post mortem human subjects and impacted on the lateral aspect by a free-flying (30 km/h) impactor below the knee joint. Tri-axial MHDs and tri-axial accelerometers were… Expand