• Publications
  • Influence
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
TLDR
In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
TLDR
IL-21 is shown to be an autocrine cytokine that is sufficient and necessary for TH17 differentiation, and serves as a target for treating inflammatory diseases.
Bcl6 Mediates the Development of T Follicular Helper Cells
TLDR
It is demonstrated that the transcription factor Bcl6 is both necessary and sufficient for TFH differentiation and subsequent B cell–mediated immunity, suggesting that it is a master regulator of this lineage.
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells*
TLDR
A pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression is demonstrated.
MAP kinases in the immune response.
TLDR
Recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses in mammalian species is summarized.
TH17 cells in development: an updated view of their molecular identity and genetic programming
  • C. Dong
  • Biology
    Nature Reviews Immunology
  • 1 May 2008
TLDR
The current knowledge of the unique gene expression, cytokine-mediated regulation and transcriptional programming of TH17 cells is summarized, and the personal perspectives on the future studies that are required to elucidate this lineage in more detail are provided.
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