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Tools for neuroanatomy and neurogenetics in Drosophila
- B. Pfeiffer, Arnim Jenett, G. Rubin
- BiologyProceedings of the National Academy of Sciences
- 15 July 2008
The results suggest that the D. melanogaster genome contains >50,000 enhancers and that multiple enhancers drive distinct subsets of expression of a gene in each tissue and developmental stage.
Drosophila Neuroblasts Sequentially Express Transcription Factors which Specify the Temporal Identity of Their Neuronal Progeny
Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal.
Neural stem cells: balancing self-renewal with differentiation
- C. Doe
- 1 May 2008
If the authors can better understand how stem cells balance self-renewal versus differentiation, it will significantly advance their knowledge of embryogenesis, cancer biology and brain evolution, as well as the use of stem cells for therapeutic purposes.
Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system.
- C. Doe
- 1 December 1992
Using molecular lineage markers, it is shown that each neuroblast forms at a stereotyped time and position, and the neuroblast pattern is indistinguishable between thoracic and abdominal segments, setting the stage for investigating neuroblast specification and the mechanisms controlling neuroblast cell lineages.
Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation
It is concluded that cortical aPKC kinase activity is a potent inducer of neuroblast self-renewal, as well as ectopic cortical localization of atypical protein kinase C (aPKC), in Drosophila neuroblasts.
Unwrapping Glial Biology Gcm Target Genes Regulating Glial Development, Diversification, and Function
Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets.
Novel conclusions are made that neuroblasts at similar dorsoventral positions, but not anteroposterior positions, often generate similar cell lineages, and that clones very late in embryonic development, which reveals novel cell types and axon/dendrite complexity, are analyzed.
The embryonic central nervous system lineages of Drosophila melanogaster. I. Neuroblast lineages derived from the ventral half of the neuroectoderm.
17 embryonic NB lineages derived from the ventral half of the neuroectoderm of Drosophila are described and previously identified neural cell types were linked to particular lineages and a systematic terminology for the ventrals nerve cord neurons is introduced.
The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts
It is proposed that Mud is a functional orthologue of mammalian NuMA and Caenorhabditis elegans Lin-5, and that Mud coordinates spindle orientation with cortical polarity to promote asymmetric cell division.