• Publications
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Tools for neuroanatomy and neurogenetics in Drosophila
We demonstrate the feasibility of generating thousands of transgenic Drosophila melanogaster lines in which the expression of an exogenous gene is reproducibly directed to distinct small subsets ofExpand
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Drosophila Neuroblasts Sequentially Express Transcription Factors which Specify the Temporal Identity of Their Neuronal Progeny
Neural precursors often generate distinct cell types in a specific order, but the intrinsic or extrinsic cues regulating the timing of cell fate specification are poorly understood. Here we show thatExpand
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Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal.
An important question in stem cell biology is how a cell decides to self-renew or differentiate. Drosophila neuroblasts divide asymmetrically to self-renew and generate differentiating progeny calledExpand
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Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation
How a cell chooses to proliferate or to differentiate is an important issue in stem cell and cancer biology. Drosophila neuroblasts undergo self-renewal with every cell division, producing anotherExpand
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Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system.
  • C. Doe
  • Biology, Medicine
  • Development
  • 1 December 1992
The first step in generating cellular diversity in the Drosophila central nervous system is the formation of a segmentally reiterated array of neural precursor cells, called neuroblasts.Expand
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Neural stem cells: balancing self-renewal with differentiation
  • C. Doe
  • Biology, Medicine
  • Development
  • 1 May 2008
Stem cells are captivating because they have the potential to make multiple cell types yet maintain their undifferentiated state. Recent studies of Drosophila and mammalian neural stem cells haveExpand
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Unwrapping Glial Biology Gcm Target Genes Regulating Glial Development, Diversification, and Function
Glia are the most abundant cell type in the mammalian brain. They regulate neuronal development and function, CNS immune surveillance, and stem cell biology, yet we know surprisingly little aboutExpand
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Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.
Regulation of stem cell self-renewal versus differentiation is critical for embryonic development and adult tissue homeostasis. Drosophila larval neuroblasts divide asymmetrically to self-renew, andExpand
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Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets.
An experimental analysis of neurogenesis requires a detailed understanding of wild-type neural development. Recent DiI cell lineage studies have begun to elucidate the family of neurons and gliaExpand
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Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells
  • J. Boone, C. Doe
  • Biology, Medicine
  • Developmental neurobiology
  • 1 August 2008
Mammalian neural stem cells generate transit amplifying progenitors that expand the neuronal population, but these type of progenitors have not been studied in Drosophila. The Drosophila larval brainExpand
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