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Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.
The epidermal growth factor receptor (EGFR) is overexpressed in a significant percentage of carcinomas and contributes to the malignant phenotype. CP-358,774 is a directly acting inhibitor of humanExpand
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Vitamin D and Calcium Intakes from Food or Supplements and Mammographic Breast Density
Background: A better understanding of factors that affect breast density, one of the strongest breast cancer risk indicators, may provide important clues about breast cancer etiology and prevention.Expand
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Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women.
BACKGROUND Vitamin D status, determined on the basis of 25-hydroxyvitamin D [25(OH)D] concentrations, is associated with the risk of several diseases. Vitamin D binding protein (DBP) is the majorExpand
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Insulin-Like Growth Factor-I, IGF-Binding Protein-3, and Mammographic Breast Density
Some studies have suggested that insulin-like growth factor (IGF) pathway is related to premenopausal breast density, one of the strongest known breast cancer risk factors. This study was designedExpand
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Can pain be managed through the Internet? A systematic review of randomized controlled trials
&NA; Given the increasing penetration and health care related use of the Internet, we examined the evidence on the impact of Internet‐based interventions on pain. A search of Medline, CINAHL,Expand
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An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteria.
Arsenic is a known toxic metalloid, whose trivalent and pentavalent ions can inhibit many biochemical processes. Operons which encode arsenic resistance have been found in multicopy plasmids fromExpand
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Influence of insulin-like growth factors on the strength of the relation of vitamin D and calcium intakes to mammographic breast density.
Diets with higher vitamin D and calcium contents were found associated with lower mammographic breast density and breast cancer risk in premenopausal women. Because laboratory studies suggest thatExpand
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A pilot study to evaluate the feasibility of individualized yoga for inpatient children receiving intensive chemotherapy
BackgroundFatigue is an important problem in paediatric cancer patients and yoga may be an effective intervention. The primary objective was to determine the feasibility of individualized yoga forExpand
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Factors associated with upgrading to malignancy at surgery of atypical ductal hyperplasia diagnosed on core biopsy.
Previous studies have shown that 4-54% of breast lesions reported on core biopsies as atypical ductal hyperplasia (ADH) are upgraded on further excision to ductal carcinoma in situ (DCIS) or invasiveExpand
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Vitamin D, calcium, and mammographic breast densities.
Vitamin D and calcium are being evaluated as potential breast cancer prevention agents. This study reports on the relation of dietary vitamin D and calcium to mammographic breast densities, one ofExpand
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