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Conservation of hearing and protection of hair cells in cochlear implant patients' with residual hearing
This review covers the molecular mechanisms involved in hair cell and hearing losses which can result from trauma generated during the process of cochlear implantation and the contributions of bothExpand
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Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha–induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes
OBJECTIVE Determine the molecular mechanism(s) behind tumor necrosis factor-alpha (TNFalpha)-induced loss of auditory hair cells and the ability of dexamethasone base (DXMb) to protect againstExpand
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Dexamethasone protects auditory hair cells against TNFα-initiated apoptosis via activation of PI3K/Akt and NFκB signaling
BACKGROUND Tumor necrosis factor alpha (TNFalpha) is associated with trauma-induced hearing loss. Local treatment of cochleae of trauma-exposed animals with a glucocorticoid is effective in reducingExpand
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Spiral ganglion cells and macrophages initiate neuro-inflammation and scarring following cochlear implantation
Conservation of a patient's residual hearing and prevention of fibrous tissue/new bone formation around an electrode array are some of the major challenges in cochlear implant (CI) surgery. AlthoughExpand
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Mechanisms of hearing loss from trauma and inflammation: otoprotective therapies from the laboratory to the clinic.
This article reviews a series of in vitro and in vivo studies that examined the otoprotective efficacy of locally delivered dexamethasone and explored the mechanisms by which dexamethasone protectsExpand
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Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma
Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death ofExpand
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Dexamethasone treatment of tumor necrosis factor-alpha challenged organ of Corti explants activates nuclear factor kappa B signaling that induces changes in gene expression that favor hair cell
The objective was to determine the role of nuclear factor kappa B (NFκB) in dexamethasone base (DXMb) protection of auditory hair cells from tumor necrosis factor-alpha (TNFα)-induced loss on geneExpand
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Blocking Pro-Cell-Death Signal Pathways to Conserve Hearing
The programmed cell death of stress-damaged auditory hair cells can occur through a variety of signal pathways, and therapeutic modalities that block pro-cell-death pathways are being developed andExpand
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Biopolymer-Released Dexamethasone Prevents Tumor Necrosis Factor &agr;-Induced Loss of Auditory Hair Cells In Vitro: Implications Toward the Development of a Drug-Eluting Cochlear Implant Electrode
Hypothesis: Polymer-eluted dexamethasone (DXM) will retain its ability to protect against tumor necrosis factor &agr; (TNF&agr;)-induced hair cell (HC) loss. Background: TNF&agr; has been shown to beExpand
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Local drug delivery to conserve hearing: mechanisms of action of eluted dexamethasone within the cochlea
Introduction Dexamethasone is a synthetic corticosteroid that is routinely administered via intratympanic injections for the treatment of sudden idiopathic sensorineural hearing loss (Plontke et al.,Expand
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