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Genomic Alterations and Allelic Imbalances Are Strong Prognostic Predictors in Osteosarcoma
TLDR
Structural chromosomal alterations detected by single nucleotide polymorphism analysis provide a simple but robust parameter to anticipate response to chemotherapy and might help to better predict the clinical course of osteosarcoma patients at the time of initial diagnosis and to adapt neoadjuvant treatment in patients resistant to the current protocols. Expand
Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors.
TLDR
It is concluded that non-small cell lung cancer shows a specific Cox-/downstream-enzyme expression pattern, which is specifically altered in lung tumor cells and tumor supplying vessels in contrast to normal lung tissue, which may have major impact on tumor progression and tumor- associated inflammation via an altered prostanoid metabolism with consecutive tumor-associated blood flow distribution. Expand
Innovative immunohistochemistry identifies MMP-9 expressing macrophages at the invasive front of murine HCC.
TLDR
MMP-9 expressing macrophages are involved in matrix remodelling at the invasive tumor front of HCC, and the described staining protocol provides a simple yet powerful extension of conventional immuno-histochemistry, facilitating visualization of at least three different antigens plus nuclei in one single histological section. Expand
Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis
TLDR
Signaling pathways of liver cell damage and compensatory liver regeneration in combination with enhanced inflammation appear to be crucial for the spontaneous development of tumors in AL mice on WD. Expand
MicroRNA-34c Inversely Couples the Biological Functions of the Runt-related Transcription Factor RUNX2 and the Tumor Suppressor p53 in Osteosarcoma*
TLDR
A novel p53-miR-34c-RUNX2 network controls cell growth of osseous cells and is compromised in OS, which is a primary bone tumor that is most prevalent during adolescence. Expand
Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4−/− mice
TLDR
The present study is the first to identify that both BM‐derived fibrocytes and HSC are involved in biliary fibrogenesis in Abcb4−/− mice, and suggests that changes in immunity subsequent to BM‐Tx may alter hepatic fibrosis. Expand
Quantitative CT imaging of the spatio-temporal distribution patterns of vasa vasorum in aortas of apoE-/-/LDL-/- double knockout mice.
TLDR
Atherosclerotic lesion type is correlated to the number and cross-sectional area of VV in different aortic segments in apoE-/-/LDL-/- mice. Expand
Scar sarcoidosis on a finger mimicking a rapidly growing soft tissue tumour: a case report
TLDR
A 33-year-old carpenter who developed scar sarcoidosis on his right index finger 4 years after the tendon of the long digital flexor got accidentally cut by an angle grinder is presented. Expand
Paraneoplastic neurological syndromes in patients with carcinoid
TLDR
Four patients with a Paraneoplastic neurological syndromes associated with carcinoid are reported, with the majority being a serotonin‐related myopathy. Expand
[Very rare cases of periprosthetic malignant neoplasms : Data from 4000 cases of endoprosthetic joint replacements from the histopathologic implant register].
TLDR
A retrospective data analysis based on the revised SLIM-consensus-classification, which defines eight different failure mechanisms, indicates that malignant neoplasia is a very rare cause of endoprosthetic joint replacement and statistical significance in implant durability between the different SLIM types. Expand
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