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Monomeric Nucleoprotein of Influenza A Virus
TLDR
The phosphorylation sites on nucleoprotein isolated from virus particles were determined and it was found that serine 165 was phosphorylated and conserved in all influenza A and B viruses. Expand
Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex
TLDR
This study rationalizes the stabilizing role of the loop-closing GA base pairs in kissing complexes and may help the development or improvement of drugs against RNA loops of viruses or pathogens as well as the conception of biochemical tools targeting RNA hairpins involved in important biological functions. Expand
Is a Closing “GA Pair” a Rule for Stable Loop-Loop RNA Complexes?*
TLDR
RNA hairpin aptamers specific for the trans-activation-responsive (TAR) RNA element of human immunodeficiency virus type 1 were identified by in vitro selection and the GA pair is a key determinant which accounts for the 50-fold increased stability of the TAR-aptamer complex. Expand
Structure-Based Discovery of the Novel Antiviral Properties of Naproxen against the Nucleoprotein of Influenza A Virus
TLDR
It is reported here that monomeric nucleoprotein can be inhibited by a small molecule binding in its RNA binding groove, resulting in a novel antiviral against influenza A virus. Expand
Conformational changes of cytochromes P-450cam and P-450lin induced by high pressure.
TLDR
The results presented herein support a view that these two bacterial cytochromes have large structural differences and suggest a picture in which the gellike cortex of each protein may play an essential role in stability and function. Expand
LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1.
TLDR
Evidence is provided that LNA modifications alternated with DNA can generate stable structured RNA mimics for interacting with folded RNA targets and confer good protection towards nuclease digestion. Expand
LNA derivatives of a kissing aptamer targeted to the trans-activating responsive RNA element of HIV-1.
TLDR
This hairpin aptamer binds to its target through loop-loop interactions and is derived chemically modified R06 aptamers that show improved nuclease resistance and affinity for TAR. Expand
MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G
TLDR
An original and complex system targeting the host immunoglobulins, playing a potentially key role in the immunity evasion by mycoplasmas is highlighted. Expand
Photoacoustic calorimetry of proteins.
TLDR
Time-resolved photoacoustic calorimetry is fast becoming a technique to probe conformational dynamics in proteins and has been used successfully to identify the residues that play important roles in the ligand binding to both Mb and cytochrome P450cam. Expand
Mutagenesis of a single hydrogen bond in cytochrome P-450 alters cation binding and heme solvation.
TLDR
Removal of a single hydrogen bond via site-directed mutagenesis of tyrosine 96 to phenylalanine 96 defines this aspect of the protein structure as responsible for the linkage between cation and substrate cooperativities, the degree of spin state conversion resulting from water access via macromolecule and substrate dynamics, and suggests a specific location for the cation binding site. Expand
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