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Glutamatergic Afferents of the Ventral Tegmental Area in the Rat
TLDR
This work found glutamatergic neurons innervating the VTA in almost all structures projecting there and that a majority of these are subcortical and VGLUT2 mRNA positive.
TASK-3, a Novel Tandem Pore Domain Acid-sensitive K+Channel
TLDR
Exercise of TASK-3 in Xenopus oocytes revealed an outwardly rectifying K+ current that was strongly decreased in the presence of lower extracellular pH, and substitution of the histidine residue His-98 by asparagine or tyrosine abolished pH sensitivity.
Molecular Cloning and Functional Expression of KCNQ5, a Potassium Channel Subunit That May Contribute to Neuronal M-current Diversity*
TLDR
It is suggested that KCNQ5 may contribute to a diversity of heteromeric channels underlying native neuronal M-currents, which are differentially expressed in subregions of the brain and in skeletal muscle.
THIK-1 and THIK-2, a Novel Subfamily of Tandem Pore Domain K+ Channels* 210
TLDR
Two cDNAs encoding novel K+channels, THIK-1 and THik-2 (tandem pore domainhalothane inhibited K +channel), were isolated from rat brain and showed that rTHIK-2 is strongly expressed in most brain regions, whereas rTHik-1 expression is more restricted.
Expression Pattern in Brain of TASK-1, TASK-3, and a Tandem Pore Domain K+ Channel Subunit, TASK-5, Associated with the Central Auditory Nervous System
TLDR
HTASK-5 K(+) channels, possibly in conjunction with auxiliary proteins, may play a role in the transmission of temporal information in the auditory system and be defined as molecular targets for extracellular protons and volatile anesthetics.
pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.
TLDR
The results provide molecular understanding for normal pH gating of K(ir) channels as well as for the channel defects found in patients with antenatal Bartter syndrome.
Resting Potential and Submembrane Calcium Concentration of Inner Hair Cells in the Isolated Mouse Cochlea Are Set by KCNQ-Type Potassium Channels
TLDR
KCNQ channels set the resting membrane potential of IHCs in the isolated organ of Corti and thus maintain [Ca2+]i at low levels, providing a novel explanation for the progressive hearing loss (DFNA2) observed in patients with defective KCNQ4 genes.
The Epithelial Inward Rectifier Channel Kir7.1 Displays Unusual K+ Permeation Properties
TLDR
Rat and human cDNAs were isolated that both encoded a 360 amino acid polypeptide with a tertiary structure typical of inwardly rectifying K+ channel (Kir) subunits and showed various unique residues at conserved sites, particularly near the pore region.
Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea‐pig cardiomyocytes
TLDR
The results suggest that the large‐conductance inward rectifier channels found in guinea‐pig cardiomyocytes (34.0 pS) correspond to gpKir2.2.
Interaction with 14‐3‐3 proteins promotes functional expression of the potassium channels TASK‐1 and TASK‐3
TLDR
It is suggested that interaction of 14‐3‐3 with TASK‐1 or TASk‐3 may promote the trafficking of the channels to the surface membrane and could be co‐immunoprecipitated in synaptic membrane extracts and postsynaptic density membranes.
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