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Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
TLDR
It is reported that placental growth factor (PGF) regulates inter- and intramolecular cross talk between the VEGF RTKs Flt1 and Flk1, which is likely to have therapeutic implications, as treatment with VegF/PGF heterodimer or a combination of VEGf plus PGF increased ischemic myocardial angiogenesis in a mouse model that was refractory to V EGF alone.
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Definitions and guidelines for research on antibiotic persistence
TLDR
Scientists working on the response of bacteria to antibiotics define antibiotic persistence and provide practical guidance on how to study bacterial persister cells, and provide a guide to measuring persistence.
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Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins
TLDR
Structural homology modelling of all annotated Fic proteins indicates that inhibition by αinh is universal and conserved through evolution, as the inhibitory motif is present in ∼90% of all putatively adenylylation-active FIC domains, including examples from all domains of life and from viruses.
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A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells.
TLDR
It is exemplarily shown that the C terminus of such a conjugative relaxase mediates protein transfer through the Bartonella henselae VirB/VirD4 system into HEC, which may represent the evolutionary origin of the here defined T4S signal for protein transfer into human cells.
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A novel vascular endothelial growth factor encoded by Orf virus, VEGF‐E, mediates angiogenesis via signalling through VEGFR‐2 (KDR) but not VEGFR‐1 (Flt‐1) receptor tyrosine kinases
TLDR
VEGF‐E is thus a potent angiogenic factor selectively binding to VEGF receptor‐2 alone can efficiently stimulate angiogenesis, and strongly indicates that activation of V EGF receptor-2 aloneCan efficiently stimulateAngiogenesis.
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Genome‐wide analysis of transcriptional hierarchy and feedback regulation in the flagellar system of Helicobacter pylori
TLDR
Flagellar basal body components FlhA and FlhF were characterized as functional equivalents to master regulators in H. pylori, as their absence led to a general reduction of transcripts in the RpoN and FliA regulons, and of 24 genes newly attributed to intermediate regulons.
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The VirB type IV secretion system of Bartonella henselae mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells
TLDR
It is demonstrated that the type IV secretion system (T4SS) VirB T4SS also mediates most of the virulence attributes associated with B. henselae during the interaction with human endothelial cells, and that the VirB system mediates cytostatic and cytotoxic effects at high bacterial titres, which interfere with a potent VirB‐independent mitogenic activity.
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Maintenance of broad-host-range incompatibility group P and group Q plasmids and transposition of Tn5 in Bartonella henselae following conjugal plasmid transfer from Escherichia coli
TLDR
The first demonstration of conjugal plasmid transfer from Escherichia coli to Bartonella henselae is reported and transposons delivered on suicide plasmids by conjugation showed transpositional insertion into random chromosomal sites.
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Invasion and Persistent Intracellular Colonization of Erythrocytes: A Unique Parasitic Strategy of the Emerging Pathogen Bartonella
TLDR
This work dissects the process of Bartonella erythrocyte parasitism in experimentally infected animals using a novel approach for tracking blood infections based on flow cytometric quantification of green fluorescent protein–expressing bacteria during their interaction with in vivo–biotinylated ERYthrocytes.
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Intruders below the Radar: Molecular Pathogenesis of Bartonella spp
TLDR
Current knowledge on the molecular processes underlying both the infection strategy and pathogenesis of Bartonella are compiled and their connection to the clinical presentation of human patients is discussed, which ranges from minor complaints to life-threatening disease.
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