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Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labelling for marking S phase cells in paraffin sections from animal and human tissues
TLDR
Hydrolysis with 2 N HCl prior to immunocytochemistry somewhat improved the results with Bouin or Carnoy and markedly augmented the intensity of the peroxidase reactions in formaldehyde and in methanol‐fixed tissues.
Iron chelators inhibit the growth and induce the apoptosis of Kaposi's sarcoma cells and of their putative endothelial precursors.
TLDR
Results show that iron deprivation inhibits the growth and induces the apoptosis of Kaposi's sarcoma cells and of their putative endothelial precursors, which suggests that iron chelators may represent a potential therapeutic approach for the treatment of Kapos's Sarcoma.
Endogenous interleukin-10 modulates fibrosis and regeneration in experimental chronic pancreatitis.
TLDR
Endogenous IL-10 controls the regeneration phase and limits the severity of fibrosis and glandular atrophy induced by repeated episodes of acute pancreatitis in mice.
Comparison of methods based on annexin‐V binding, DNA content or TUNEL for evaluating cell death in HL‐60 and adherent MCF‐7 cells
TLDR
In MCF‐7 cells DNA strand breaks cannot be effectively labelled, which may be due to inaccessibility of 3′‐OH ends in the breaks to exogenous terminal deoxynucleotidyl transferase, depending on the cell type.
Interleukin‐10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice
TLDR
In conclusion, endogenous IL‐10 marginally affects the hepatocyte necrosis although it controls the acute inflammatory burst induced by CCl4 during liver repair, it limits the proliferative response of hepatocytes and the development of fibrosis.
Hepatocyte proliferative activity in human liver cirrhosis.
TLDR
This prospective study strengthens the previous observation that, in cirrhosis, hepatocyte proliferative activity, as evaluated by the PCNA-LI, provides information on liver functional reserve as well as on the patient's prognosis.
G1/S Cyclins Interact with Regulatory Subunit of PKA via A-Kinase Anchoring Protein, AKAP95
TLDR
It is shown that these G1/S cyclins can interact with RIIsubunit of PKAα through AKAP95, and the presence of alternate complexes cyclin-CDK and cyclin D/E-AKAP95-PKA suggest different roles of G 1/Scyclins and a wider biological importance of these interactions in cells.
Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP.
TLDR
The data suggest that p76RBE could play a key role between RhoB and potential downstream elements needed under stimulation of the thyrotropin/cAMP pathway in thyrocytes and responsible for intracellular motile phenomena such as the endocytosis involved in the thyroid secretory process.
A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95.
TLDR
It is hypothesized that the interaction between AKAP95 and D-type cyclins might serve to facilitate the emerging regulatory role of cyclin D-CDK4 in the formation of the prereplication complex at the DNA replication origins.
Chronic alcohol exposure sensitizes mice to galactosamine-induced liver injury through enhanced keratinocyte chemoattractant and defective IL-10 production.
TLDR
Enhancement of GAL-induced liver injury by ethanol is associated with an imbalance between proinflammatory cytokines and the anti-inflammatory cytokine IL-10 and depends on gut bacterial flora.
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