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Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products*♦
TLDR
In vitro specificities of prostanoid enzymes and receptors toward EPA-derived, 3-series versus AA- derived, 2-series prostanoids substrates and products are reported and biochemical data predict that increasing phospholipid EPA/AA ratios in cells would dampen prostanoidal signaling. Expand
Molecular Distinction of Phosphatidylcholine Synthesis between the CDP-Choline Pathway and Phosphatidylethanolamine Methylation Pathway*
TLDR
A profound distinction in PC profiles between the CDP-choline pathway and the PE methylation pathway was revealed, which may contribute to the different functions of these two pathways in the liver. Expand
Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation.
TLDR
The concepts that COX-2 gene transcription can involve at least six different cis-acting promoter elements interacting with trans-acting factors generated by multiple, different signaling pathways are developed. Expand
Intracellular Assembly of Very Low Density Lipoproteins Containing Apolipoprotein B100 in Rat Hepatoma McA-RH7777 Cells*
TLDR
Results suggest that VLDL assembly in McA-RH7777 cells takes place in compartments at the distal end of the secretory pathway. Expand
Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients
TLDR
Examination of changes in gene expression as iPSC derived from well-characterized patients differentiate into neurons found BP neurons were significantly different than controls in their transcriptional profile, and lithium pretreatment of BP neurons significantly altered their calcium transient and wave amplitude. Expand
Molecular species composition of rat liver phospholipids by ESI-MS/MS: the effect of chromatography.
TLDR
Using electrospray ionization tandem mass spectrometry (ESI-MS/MS) this study shows that the loss of glycerophospholipid after chromatography was unevenly distributed across the GPL molecular species, suggesting that aldehydes were generated by the oxidation of unsaturated fatty acids. Expand
Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice
TLDR
Observations of age-dependent spontaneous regression of advanced cancers in a colony of mice suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer. Expand
Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry.
TLDR
It is intriguing that each tissue was found to possess a unique signature of GPL profile that may be used to identify unknown tissues and may also set reference points for studying changes of GPL metabolism in different physiological and pathological conditions. Expand
Disruption of Choline Methyl Group Donation for Phosphatidylethanolamine Methylation in Hepatocarcinoma Cells*
TLDR
It is demonstrated for the first time that choline contributed to phosphatidylcholine (PC) synthesis both as an intact choline moiety via the CDP-choline pathway and as a methyl donor via PE methylation pathway. Expand
Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells
TLDR
It is demonstrated that dissociated human pluripotent stem cells (PSCs) are intrinsically programmed to form lumens, and this system can provide a powerful model for investigation of this process in a controlled environment. Expand
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