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Probiotic bacteria enhance murine and human intestinal epithelial barrier function.
TLDR
In vitro studies showed that epithelial barrier function and resistance to Salmonella invasion could be enhanced by exposure to a proteinaceous soluble factor secreted by the bacteria found in the VSL#3 compound.
Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases
TLDR
Results of the study suggest that manipulation of intestinal flora should be taken into consideration as possible adjunctive therapy in some types of chronic liver disease.
DNA from probiotic bacteria modulates murine and human epithelial and immune function.
TLDR
DNA from probiotic bacteria can limit epithelial proinflammatory responses in vivo and in vitro and systemic and oral administration of VSL3 DNA ameliorates inflammatory responses.
Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition.
TLDR
The resulting inhibition of nuclear factor-kappaB and increased expression of heat shock proteins may account for the anti-inflammatory and cytoprotective effects reported for probiotics and may be a novel mechanism of microbial-epithelial interaction.
The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells.
TLDR
Among the three bacterial groups contained in VSL#3, the Lactobacillus species were the strongest potentiator of mucin secretion in vitro, and this findings contribute to a better understanding of the complex and beneficial interaction between colonic epithelial cells and intestinal bacteria.
Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration.
TLDR
The urinary excretion of oxalate, a major risk factor for renal stone formation and growth in patients with idiopathic calcium-oxalate urolithiasis, can be greatly reduced with treatment using a high concentration of freeze-dried lactic acid bacteria.
Apoptosis and surgical trauma: dysregulated expression of death and survival factors on peripheral lymphocytes.
TLDR
In the early postoperative period, surgical trauma under general anesthesia induces an intracellular perturbation on peripheral lymphocytes, resulting in both up-regulation of death-signaling factors and down- regulation of survival-signalling factors.
Use of a probiotic to decrease enteric hyperoxaluria.
TLDR
Manipulation of gastrointestinal (GI) flora can influence urinary oxalate excretion to reduce urinary supersaturation levels, which could have a salutary effect on stone formation rates.
Cytokines in the sera of patients with pemphigus vulgaris: interleukin-6 and tumour necrosis factor-alpha levels are significantly increased as compared to healthy subjects and correlate with disease
TLDR
The data presented support an involvement of at least IL-6 and TNF-alpha in the biological modifications associated with PV manifestations, which are found to be significantly higher in PV patients than in normal controls.
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