Coumarins: old compounds with novel promising therapeutic perspectives.
- M. Riveiro, N. de Kimpe, C. Davio
- Chemistry, BiologyCurrent Medicinal Chemistry
- 1 May 2010
The present review highlights the current progress in the development of coumarin scaffolds for drug discovery as novel anti-cancer agents and the translation of current knowledge into new potential lead compounds and the repositioning of known compounds for the treatment of cancer.
Multidrug Resistance Protein 4 (MRP4/ABCC4) Regulates cAMP Cellular Levels and Controls Human Leukemia Cell Proliferation and Differentiation*
- S. Copsel, Corina I. García, C. Davio
- Biology, ChemistryJournal of Biological Chemistry
- 4 January 2011
It is shown that intracellular cAMP levels not only in U937 cells but also in other acute myeloid leukemia cell lines are also regulated by multidrug resistance-associated proteins (MRPs), particularly MRP4, and provided the first evidence that MRP 4 may represent a new potential target for leukemia differentiation therapy.
Semen Promotes the Differentiation of Tolerogenic Dendritic Cells
- F. Remes Lenicov, C. Rodríguez Rodrígues, A. Ceballos
- BiologyJournal of Immunology
- 15 November 2012
It is shown that seminal plasma redirects the differentiation of human dendritic cells (DCs) toward a regulatory profile, which might favor fertility, but might also compromise the capacity of the receptive partner to mount an effective immune response against sexually transmitted pathogens.
Histamine Improves Antigen Uptake and Cross-Presentation by Dendritic Cells1
- M. M. Amaral, C. Davio, M. Vermeulen
- BiologyJournal of Immunology
- 15 September 2007
The results support that histamine may favor cross-presentation of soluble allergens by DCs enabling the activation of allergen-specific T CD8+ cells, which appears to play an important role in the development of allergic responses in the airway.
Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells.
- M. Riveiro, A. Moglioni, C. Davio
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 1 March 2008
Induction of mammary tumors in rat by intraperitoneal injection of NMU: histopathology and estral cycle influence.
- E. Rivera, N. Andrade, R. Bergoc
- MedicineCancer Letters
- 11 November 1994
Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.
The results indicate that histamine activates several mechanisms involved in the induction of differentiation, such as cAMP and c-fos production, but fails to promote differentiation of U937 cells, apparently due to the rapid desensitization of H2 receptors.
Mepyramine, a Histamine H1 Receptor Inverse Agonist, Binds Preferentially to a G Protein-coupled Form of the Receptor and Sequesters G Protein*
- C. Fitzsimons, F. Monczor, N. Fernández, C. Shayo, C. Davio
- Biology, ChemistryJournal of Biological Chemistry
- 13 August 2004
The present work finds that mepyramine is able to decrease the basal constitutive activity of the guinea pig H1 receptor, to bind with high affinity to a Gq/11 protein-coupled form of the receptor and to reduce G protein availability for other non-related receptors associated with the same signaling pathway.
G‐protein‐coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß‐d‐glucuronide‐induced cholestasis
- A. Zucchetti, I. Barosso, E. J. S. Pozzi
- BiologyHepatology
- 1 March 2014
Activation of GPR30‐AC‐PKA is a key factor in the alteration of canalicular transporter function and localization induced by E17G, and may be the first event in the cascade of signaling activation.
Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells.
- M. Riveiro, Dominick Maes, C. Davio
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 15 September 2009
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