• Publications
  • Influence
Circulating histones are mediators of trauma-associated lung injury.
RATIONALE Acute lung injury is a common complication after severe trauma, which predisposes patients to multiple organ failure. This syndrome largely accounts for the late mortality that arises andExpand
  • 311
  • 26
Activation of ATP‐dependent K+ channels by hypoxia in smooth muscle cells isolated from the pig coronary artery.
1. The perforated patch technique with amphotericin B was used to record whole‐cell currents activated by hypoxia in smooth muscle cells, isolated enzymatically from pig coronary arteries. 2.Expand
  • 127
  • 10
Adenosine‐activated potassium current in smooth muscle cells isolated from the pig coronary artery.
1. The perforated patch technique with nystatin or amphotericin was used to record whole cell currents activated by adenosine in smooth muscle cells isolated enzymatically from pig coronary arteries.Expand
  • 198
  • 8
The properties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle.
1. Whole‐cell potassium currents were studied in single smooth muscle cells enzymatically isolated from pig coronary arteries. 2. In cells isolated from small diameter branches of the left anteriorExpand
  • 143
  • 7
Targeting of an A Kinase-anchoring Protein, AKAP79, to an Inwardly Rectifying Potassium Channel, Kir2.1*
Protein kinase A (PKA) is targeted to discrete subcellular locations close to its intended substrates through interaction with A kinase-anchoringproteins (AKAPs). Ion channels represent a diverse andExpand
  • 66
  • 5
Caveolae Localize Protein Kinase A Signaling to Arterial ATP-Sensitive Potassium Channels
Arterial ATP-sensitive K+ (KATP) channels are critical regulators of vascular tone, forming a focal point for signaling by many vasoactive transmitters that alter smooth muscle contractility and soExpand
  • 113
  • 4
  • PDF
Human CRP Defends against the Toxicity of Circulating Histones
C-reactive protein (CRP) is an acute-phase protein that plays an important defensive role in innate immunity against bacterial infection, but it is also upregulated in many noninfectious diseases.Expand
  • 79
  • 4
  • PDF
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
The second messenger cAMP plays a central role in mediating vascular smooth muscle relaxation in response to vasoactive transmitters and in strengthening endothelial cell-cell junctions that regulateExpand
  • 43
  • 4
The PSD95–nNOS interface
The stress-activated protein kinase p38 and nitric oxide (NO) are proposed downstream effectors of excitotoxic cell death. Although the postsynaptic density protein PSD95 can recruit theExpand
  • 64
  • 3
  • PDF
Direct Interaction between the Actin-binding Protein Filamin-A and the Inwardly Rectifying Potassium Channel, Kir2.1*
The role of filamins in actin cross-linking and membrane stabilization is well established, but recently their ability to interact with a variety of transmembrane receptors and signaling proteins hasExpand
  • 93
  • 3