CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease.
- N. Barnich, F. Carvalho, A. Darfeuille‐Michaud
- Medicine, BiologyJournal of Clinical Investigation
- 1 June 2007
In vitro studies show that there is increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-gamma or TNF-alpha stimulation and after infection with AIEC bacteria, indicating that AIEC can promote its own colonization in CD patients.
Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM
- F. Carvalho, N. Barnich, A. Darfeuille‐Michaud
- Biology, MedicineJournal of Experimental Medicine
- 28 September 2009
The hypothesis that in Crohn's disease patients having an abnormal intestinal expression of CEACAM6, AIEC bacteria via type 1 pili expression can colonize the intestinal mucosa and induce gut inflammation is strongly supported.
Colonization of the Human Gut by E. coli and Colorectal Cancer Risk
- M. Bonnet, E. Buc, A. Darfeuille‐Michaud
- Medicine, BiologyClinical Cancer Research
- 13 December 2013
Findings support that pathogenic E. coli could be a cofactor in pathogenesis of colorectal cancer.
Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype
- A. Cougnoux, G. Dalmasso, R. Bonnet
- Biology, MedicineGut
- 21 March 2014
Colibactin-producing E. coli enhanced tumour growth in both xenograft and AOM/DSS models, revealing a new paradigm for carcinogenesis, in which colibactIn-induced senescence has an important role.
Involvement of the Wnt/β-Catenin Signaling Pathway in the Cellular and Molecular Mechanisms of Fibrosis in Endometriosis
- S. Matsuzaki, C. Darcha
- Medicine, BiologyPLoS ONE
- 4 October 2013
Aberrant activation of the Wnt/β-catenin pathway may be involved in mediating fibrogenesis in endometriosis.
Epithelial to mesenchymal transition-like and mesenchymal to epithelial transition-like processes might be involved in the pathogenesis of pelvic endometriosis.
- S. Matsuzaki, C. Darcha
- Medicine, BiologyHuman Reproduction
- 1 March 2012
It is hypothesized that pelvic endometriosis originates from retrograde menstruation of endometrial tissue and that EMT-like and MET-like processes might be involved in the pathogenesis of pelvic endometricriosis.
Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation.
- J. Raisch, E. Buc, A. Darfeuille‐Michaud
- Biology, MedicineWorld Journal of Gastroenterology
- 7 June 2014
In vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E. coli strain 11G5 isolated from colon cancer is able to highly persist in the gut, and to induce colon inflammation, epithelial damages and cell proliferation.
Crohn's disease‐associated Escherichia coli LF82 aggravates colitis in injured mouse colon via signaling by flagellin
- F. Carvalho, N. Barnich, P. Sauvanet, C. Darcha, A. Gelot, A. Darfeuille‐Michaud
- Medicine, BiologyInflammatory Bowel Diseases
- 1 August 2008
Crohn's disease‐associated virulent AIEC LF82 bacteria, via expression of flagella, are able to potentiate an inflammatory mucosal immune response involving increased expression of TLR5 and IPAF flagellin receptors.
Co-operation between the AKT and ERK signaling pathways may support growth of deep endometriosis in a fibrotic microenvironment in vitro.
- S. Matsuzaki, C. Darcha
- Biology, MedicineHuman Reproduction
- 1 July 2015
The serine/threonine kinase AKT and extracellular regulated kinase (ERK) signaling pathways may co-operate to support growth of deep endometriotic lesions by enhancing endometRIotic stromal cell proliferation and survival in a fibrotic microenvironment in vitro.
Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats.
- S. Matsuzaki, M. Canis, C. Darcha, R. Dallel, K. Okamura, G. Mage
- Medicine, BiologyFertility and Sterility
- 1 December 2004
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