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Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper (Th) 1/Th17 to a Th2 and Regulatory T Cell Profile
A number of recent studies testify that calcitriol alone or in combination with corticosteroids exerts strong immune modulatory activity. As a new approach, we evaluated the protolerogenic potentialExpand
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines
It has been reported that retinoic acid (RA) enhances regulatory T (T reg) cell conversion by inhibiting the secretion of cytokines that interfere with conversion. This report shows that theseExpand
FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells1
Following the present concepts, the synthetic sphingosine analog of myriocin FTY720 alters migration and homing of lymphocytes via sphingosine 1-phosphate receptors. However, several studies indicateExpand
Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
Forkhead box P3 (FOXP3)-expressing regulatory T (TReg) cells have a pivotal role in the regulation of immune responses and in the maintenance of immunological self-tolerance. These cells have emergedExpand
Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope
Subimmunogenic vaccination with an agonist mimetope of insulin converts naive T cells into regulatory T cells and prevents type 1 diabetes in NOD mice.
Enhancement of antigen-specific Treg vaccination in vivo
The conversion of naive T cells into Treg can be achieved in vivo by delivery of antigen under subimmunogenic conditions. Here we have examined several drugs for their ability to enhance theExpand
A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function.
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3+ regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation.Expand
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Immune tolerance is executed partly by Foxp3+regulatory T (Treg) cells, which suppress autoreactive T cells. In autoimmune type 1 diabetes (T1D) impaired tolerance promotes destruction ofExpand
Adipose‐tissue regulatory T cells: Critical players in adipose‐immune crosstalk
Obesity and type‐2 diabetes (T2D) are associated with metabolic defects and inflammatory processes in fat depots. FoxP3+ regulatory T cells (Tregs) control immune tolerance, and have an importantExpand
A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes
A miRNA181a/NFAT5 signaling axis promotes immune activation and interferes with the induction of regulatory T cells in islet autoimmunity. Meddling with microRNA to treat type 1 diabetes Among otherExpand
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