• Publications
  • Influence
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
TLDR
A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed. Expand
c-Myc-regulated microRNAs modulate E2F1 expression
TLDR
A mechanism through which c-Myc simultaneously activates E2F1 transcription and limits its translation, allowing a tightly controlled proliferative signal is revealed. Expand
Development of human protein reference database as an initial platform for approaching systems biology in humans.
TLDR
This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era. Expand
MYC on the Path to Cancer
  • C. Dang
  • Biology, Medicine
  • Cell
  • 30 March 2012
TLDR
The richness of the understanding of MYC is reviewed, highlighting new biological insights and opportunities for cancer therapies. Expand
c-Myc suppression of miR-23 a / b enhances mitochondrial glutaminase expression and glutamine metabolism
Altered glucose metabolism in cancer cells is termed the Warburg effect, which describes the propensity of most cancer cells to take up glucose avidly and convert it primarily to lactate, despiteExpand
Widespread microRNA repression by Myc contributes to tumorigenesis
TLDR
It is shown here that Myc regulates a much broader set of miRNAs than previously anticipated, and extensive reprogramming of the miRNA transcriptome by Myc contributes to tumorigenesis. Expand
c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
  • C. Dang
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 1 January 1999
TLDR
The c-myc gene was discovered as the cellular homolog of the retroviral v- myc oncogene 20 years ago and found to be activated in various animal and human tumors, suggesting that it is critical for development. Expand
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
TLDR
The effects of manipulating COX4 subunit expression on COX activity, ATP production, O(2) consumption, and reactive oxygen species generation indicate that the COX 4 subunit switch is a homeostatic response that optimizes the efficiency of respiration at different O( 2) concentrations. Expand
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
TLDR
It is shown that inhibition of LDHA with FX11 is an achievable and tolerable treatment for LDHA-dependent tumors and oxidative stress and cell death are critical aspects of cancer biology to consider for the therapeutical targeting of cancer energy metabolism. Expand
Otto Warburg's contributions to current concepts of cancer metabolism
TLDR
The acknowledgement for the source of Figure 1 on page 327 of this article was incorrect and has now been corrected online. Expand
...
1
2
3
4
5
...