HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
- Jung-whan Kim, Irina Tchernyshyov, G. Semenza, C. Dang
- 1 March 2006
Biology, Computer Science
Cell Metabolism
c-Myc-regulated microRNAs modulate E2F1 expression
- Kathryn A. O’Donnell, E. Wentzel, K. Zeller, C. Dang, J. Mendell
- 9 June 2005
Biology
Nature
A mechanism through which c-Myc simultaneously activates E2F1 transcription and limits its translation, allowing a tightly controlled proliferative signal is revealed.
MYC on the Path to Cancer
- C. Dang
- 30 March 2012
Biology, Chemistry
Cell
Development of human protein reference database as an initial platform for approaching systems biology in humans.
- S. Peri, J. D. Navarro, A. Pandey
- 1 October 2003
Biology
Genome Research
This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era.
c-Myc suppression of miR-23 a / b enhances mitochondrial glutaminase expression and glutamine metabolism
- P. Gao, Irina Tchernyshyov, C. Dang
- 2009
Biology
The c-Myc (hereafter referred to as Myc) oncogenic transcription factor, which is known to regulate microRNAs and stimulate cell proliferation, transcriptionally represses miR-23a and miB-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells.
Widespread microRNA repression by Myc contributes to tumorigenesis
- Tsung-Cheng Chang, Duonan Yu, J. Mendell
- 2008
Biology
Nature Genetics
It is shown here that Myc regulates a much broader set of miRNAs than previously anticipated, and extensive reprogramming of the miRNA transcriptome by Myc contributes to tumorigenesis.
c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
- C. Dang
- 1 January 1999
Biology, Medicine
Molecular and Cellular Biology
The c-myc gene was discovered as the cellular homolog of the retroviral v- myc oncogene 20 years ago and found to be activated in various animal and human tumors, suggesting that it is critical for development.
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
- R. Fukuda, Huafeng Zhang, Jung-whan Kim, L. Shimoda, C. Dang, G. Semenza
- 6 April 2007
Biology
Cell
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.
It is suggested that an increased LDH-A level is required for the growth of a transformed spheroid cell mass, which has a hypoxic internal microenvironment and is necessary for c-Myc-mediated transformation.
Otto Warburg's contributions to current concepts of cancer metabolism
- W. Koppenol, P. Bounds, C. Dang
- 1 August 2011
Medicine
Nature Reviews. Cancer
The acknowledgement for the source of Figure 1 on page 327 of this article was incorrect and has now been corrected online.
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