HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
- Jung-whan Kim, Irina Tchernyshyov, G. Semenza, C. Dang
- 1 March 2006
Biology, Computer Science
c-Myc-regulated microRNAs modulate E2F1 expression
- Kathryn A. O’Donnell, E. Wentzel, K. Zeller, C. Dang, J. Mendell
- 9 June 2005
A mechanism through which c-Myc simultaneously activates E2F1 transcription and limits its translation, allowing a tightly controlled proliferative signal is revealed.
MYC on the Path to Cancer
- C. Dang
- 30 March 2012
Development of human protein reference database as an initial platform for approaching systems biology in humans.
- S. Peri, J. D. Navarro, A. Pandey
- 1 October 2003
This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era.
c-Myc suppression of miR-23 a / b enhances mitochondrial glutaminase expression and glutamine metabolism
- P. Gao, Irina Tchernyshyov, C. Dang
The c-Myc (hereafter referred to as Myc) oncogenic transcription factor, which is known to regulate microRNAs and stimulate cell proliferation, transcriptionally represses miR-23a and miB-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells.
Widespread microRNA repression by Myc contributes to tumorigenesis
- Tsung-Cheng Chang, Duonan Yu, J. Mendell
It is shown here that Myc regulates a much broader set of miRNAs than previously anticipated, and extensive reprogramming of the miRNA transcriptome by Myc contributes to tumorigenesis.
c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
- C. Dang
- 1 January 1999
Molecular and Cellular Biology
The c-myc gene was discovered as the cellular homolog of the retroviral v- myc oncogene 20 years ago and found to be activated in various animal and human tumors, suggesting that it is critical for development.
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
- R. Fukuda, Huafeng Zhang, Jung-whan Kim, L. Shimoda, C. Dang, G. Semenza
- 6 April 2007
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.
It is suggested that an increased LDH-A level is required for the growth of a transformed spheroid cell mass, which has a hypoxic internal microenvironment and is necessary for c-Myc-mediated transformation.
Otto Warburg's contributions to current concepts of cancer metabolism
- W. Koppenol, P. Bounds, C. Dang
- 1 August 2011
Nature Reviews. Cancer
The acknowledgement for the source of Figure 1 on page 327 of this article was incorrect and has now been corrected online.