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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Target engagement is a critical factor for therapeutic efficacy. Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery.Expand
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Influence of crop rotation on soil nutrients,microbial activities and bacterial community structures
A 16-year field experiment has been carried out to investigate the influence of crop rotations on soil nutrients,microbial activities and bacterial community structures. The study includes 454Expand
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Synergetic effects of aqueous extracts of Fuzi (Radix Aconiti Lateralis Preparata) and Tubeimu (Rhizoma Bolbostemmatis) on MDA-MB-231 and SKBR3 cells
Abstract Objective To test the synergistic effects of the aqueous extract of Tubeimu (Rhizoma Bolbostemmatis) and Fuzi (Radix Aconiti Lateralis Preparata) on MDA-MB-231 and SKBR3 breast cancer cells.Expand
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Association between a polymorphism of aldosterone synthase gene and essential hypertension
[Objective]To investigate the association of the polymorphism of aldosterone synthase with essential hypertension(EH)in Dalian.[Method]Essential hypertensives 339 and healthy people 640 were enrolledExpand
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STUDY OF INTERMEDIATE FILAMENTS IN ADIANTUM PHILIPPENSE AND COMPARATIVE ANALYSIS OF KARETIN LIKE PROTEINS IN SOME PLANT SPECIES
Network of filaments, 10 nm in diameter, was detected in the frond cells of Adiantum philippense L. by selective extraction combined with whole mount electron microscopy. Western blot analysis showedExpand
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Pentamerous flowers in the genus Phytolacca have been derived from trimerous flowers-New evidence from the floral organogenesis of Phytolacca dodecandra
The floral organogenesis of Phytolacca dodecandra L′Her. (Phytolaccaceae) has been observed under both scanning electron microscope (SEM) and light microscope. The primordia of the floral appendageExpand
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Antifungal Activity in vitro of Arctium Ethanol Extract
The antimicrobial activities of arctium extract with 70% ethanol were studied in the paper.The result showed that the extract had significant antifungal effect against StreptococcusExpand
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Formin-binding Protein is Implicated in the Regulation of Hyphal Polarity Growth of Neurospora crassa
The actin cytoskeleton plays an important role in hyphal polarity growth of filamentous fungi and its dynamic property is critical for actin function.Formin is an actin-binding protein,it has beenExpand
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IAA Distribution of Anther and Pollen during Flower Development of Nicotiana tabacum L.
In this study,different stages of anthers of Nicotiana tabacum L.were detailed investigated.With the aid of DAPI(4',6-diamidino-2-phenylindole)staining,the process of pollen development wasExpand