• Publications
  • Influence
Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate
Bronchopulmonary dysplasia (BPD) is the most common, serious sequela of premature birth. Inflammation is a major contributor to the pathogenesis of BPD. Often initiated by a pulmonary fetalExpand
  • 158
  • 15
Role of neuregulin-1 beta in the developing lung.
Neuregulins play a critical role in the developing heart, nervous, and mammary systems. Neuregulin-1-induced cardiac, neuronal, and mammary differentiation is based on a cell-cell communicationExpand
  • 35
  • 5
Androgen regulation of signaling pathways in late fetal mouse lung development.
During lung development there is tension between positive and negative regulators of fibroblast-epithelial communication controlling type II cell differentiation. A clinical consequence of imbalanceExpand
  • 51
  • 2
  • PDF
ErbB4 deletion leads to changes in lung function and structure similar to bronchopulmonary dysplasia.
Neuregulin is an important growth factor in fetal surfactant synthesis, and downregulation of its receptor, ErbB4, impairs fetal surfactant synthesis. We hypothesized that pulmonary ErbB4 deletionExpand
  • 31
  • 2
  • PDF
The ErbB4 receptor in fetal rat lung fibroblasts and epithelial type II cells.
ErbB receptors are important regulators of fetal organ development, including the fetal lung. They exhibit diversity in signaling potential, acting through homo- and heterodimers to cause differentExpand
  • 18
  • 2
  • PDF
ErbB receptors in fetal endothelium--a potential linkage point for inflammation-associated neonatal disorders.
OBJECTIVE ErbB receptors and their ligands play crucial roles in development. During late gestation, they might also be involved in the pathogenesis of prematurity-associated disorders. ErbB receptorExpand
  • 27
  • 2
ErbB receptor dimerization, localization, and co‐localization in mouse lung type II epithelial cells
ErbB receptors are crucial for embryonic neuronal and cardiac development. ErbB receptor ligands neuregulin (NRG) and epidermal growth factor (EGF) play a major role in the developing lung,Expand
  • 37
  • 1
Expression and activity of epidermal growth factor receptor in late fetal rat lung is cell- and sex-specific.
Epidermal growth factor (EGF) augments late fetal lung maturation by advancing the ontogeny of fetal lung development and by stimulating surfactant synthesis. Previous studies have indicated thatExpand
  • 27
  • 1
Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung.
Sufficient pulmonary surfactant production is required for the fetal-neonatal transition, especially in preterm infants. Neuregulin (NRG) and its transmembrane receptor ErbB4 positively regulate theExpand
  • 22
  • 1
ErbB receptor regulation by dexamethasone in mouse type II epithelial cells
Glucocorticoids stimulate foetal surfactant synthesis. Therefore, they are used in impending pre-term birth. One mechanism of action on surfactant synthesis is through the induction of neuregulinExpand
  • 14
  • 1