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Regulation of Clock-Controlled Genes in Mammals
The complexity of tissue- and day time-specific regulation of thousands of clock-controlled genes (CCGs) suggests that many regulatory mechanisms contribute to the transcriptional output of the… Expand
Primary and secondary thrombocytosis in childhood
This review summarizes current data on the pathomechanisms and clinical aspects of primary and secondary thrombocytosis in childhood. Primary thrombocytosis is extremely rare in childhood, mostly… Expand
An Approach to Using Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants
OBJECTIVE. Erythropoietin has been shown to be protective against hypoxic-ischemic and inflammatory injuries in cell culture, animal models of brain injury, and clinical trials of adult humans. The… Expand
Erythropoietin mRNA expression in human fetal and neonatal tissue.
Based on animal experiments, a switch of the erythropoietin (EPO) production site from the liver in the fetus to the kidneys in the adult has been postulated. To study the switch in humans, we have… Expand
Erythropoietin acts as a trophic factor in neonatal rat intestine
BACKGROUND Erythropoietin (Epo) receptors are present on enterocytes of fetal and neonatal small bowel but the role of Epo in the bowel is not known. AIMS We tested the following hypotheses: (1)… Expand
Expression of the thrombopoietin gene in human fetal and neonatal tissues.
Thrombopoietin (TPO) regulates megakaryopoiesis and platelet production. In the adult, TPO is mainly produced by the liver and the kidneys. This study focuses on fetal and neonatal TPO mRNA… Expand
Erythropoietin gene expression in different areas of the developing human central nervous system.
- C. Dame, P. Bartmann, E. Wolber, H. Fahnenstich, D. Hofmann, J. Fandrey
- Biology, Medicine
- Brain research. Developmental brain research
- 29 December 2000
UNLABELLED Evidence from cell culture and animal experiments suggests a neuroprotective and neurotrophic function of erythropoietin (EPO). We have quantitated the distribution of EPO mRNA expression… Expand
Comprehensive genotyping and clinical characterisation reveal 27 novel NKX2-1 mutations and expand the phenotypic spectrum
- A. Thorwarth, Sarah Schnittert-Hübener, +26 authors H. Krude
- Biology, Medicine
- Journal of Medical Genetics
- 8 April 2014
Background NKX2-1 encodes a transcription factor with large impact on the development of brain, lung and thyroid. Germline mutations of NKX2-1 can lead to dysfunction and malformations of these… Expand
Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis
This meta-analysis of RCTs investigates whether prophylactic recombinant erythropoietin in preterm infants improves neurodevelopmental outcomes at 18 to 24 months’ corrected age. CONTEXT: Recombinant… Expand
The switch from fetal to adult erythropoiesis.
The story of the developmental changes in erythropoiesis is the history of oxygenation in the developing organism. The individual components of the switch from embryonic to adult erythropoiesis are… Expand