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Design challenges for hemoproteins: the solution structure of apocytochrome b5.
In order to characterize the structural and dynamic factors that determine the assembly in b hemoproteins, the solution structure of the 98-residue protein apocytochrome b5 was determined by NMRExpand
Similarities in structure between holocytochrome b5 and apocytochrome b5: NMR studies of the histidine residues.
The properties of the six histidine residues of apocytochrome b5 have been investigated by using one- and two-dimensional proton NMR spectroscopy in order to probe the structure remaining after hemeExpand
The solubilization of model Alzheimer tangles: reversing the beta-sheet conformation induced by aluminum with silicates.
  • G. Fasman, C. D. Moore
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 8 November 1994
Neurofibrillary tangles are one of two lesions found in the brain of Alzheimer disease victims. With synthetic peptide fragments of human neurofilament NF-M17 (Glu-Glu-Lys-Gly-Lys-Ser-Pro-Expand
Solubilization of beta-amyloid-(1-42)-peptide: reversing the beta-sheet conformation induced by aluminum with silicates.
Plaques are one of the two lesions found in the brain of patients with Alzheimer disease. Using a synthetic peptide corresponding to rat beta-amyloid-(1-42) (beta A4), circular dichroism (CD)Expand
Structural properties of apocytochrome b5: presence of a stable native core.
Upon removal of the heme group, the water-soluble fragment of cytochrome b5 adopts a conformation less stable and compact than that of the holoprotein [Huntley, T. E., & Strittmatter, P. (1972) J.Expand
Characterization of an independent structural unit in apocytochrome b5.
Apocytochrome b5 is a partially folded protein which contains a stable structural unit under native conditions [Moore, C.D., Al-Misky, O.N., & Lecomte, J.T.J. (1990) Biochemistry 30, 8357-8365]. InExpand
Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.
Malaria continues to be a difficult disease to eradicate largely because of the widespread populations it affects and the resistance that malaria parasites have developed against once very potentExpand
Structural and Biophysical Characterization of XIAP BIR3 G306E Mutant: Insights in Protein Dynamics and Application for Fragment‐Based Drug Design
Previous reports describe modulators of X‐linked inhibitor of apoptosis (XIAP)–caspase interaction designed from the AVPI N‐terminal peptide sequence of second mitochondria‐derived activator ofExpand
NMR detection and study of hydrolysis of HNO-derived sulfinamides.
Nitroxyl (HNO), a potential heart failure therapeutic, is known to post-translationally modify cysteine residues. Among reactive nitrogen oxide species, the modification of cysteine residues toExpand