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Visualization of Microtubule Growth in Cultured Neurons via the Use of EB3-GFP (End-Binding Protein 3-Green Fluorescent Protein)
Several microtubule binding proteins, including CLIP-170 (cytoplasmic linker protein-170), CLIP-115, and EB1 (end-binding protein 1), have been shown to associate specifically with the ends ofExpand
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Transcription factor GATA‐3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear
Patterning the vertebrate ear requires the coordinated expression of genes that are involved in morphogenesis, neurogenesis, and hair cell formation. The zinc finger gene GATA‐3 is expressed both inExpand
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A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging In Vivo
Fluorescent calcium indicator proteins, such as GCaMP3, allow imaging of activity in genetically defined neuronal populations. GCaMP3 can be expressed using various gene delivery methods, such asExpand
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Mammalian Golgi‐associated Bicaudal‐D2 functions in the dynein–dynactin pathway by interacting with these complexes
Genetic analysis in Drosophila suggests that Bicaudal‐D functions in an essential microtubule‐based transport pathway, together with cytoplasmic dynein and dynactin. However, the molecular mechanismExpand
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L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns.
L1 is a neural cell adhesion molecule mainly involved in axon guidance and neuronal migration during brain development. Mutations in the human L1 gene give rise to a complex clinical picture, withExpand
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Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses
Mammals can be trained to make a conditioned movement at a precise time, which is correlated to the interval between the conditioned stimulus and unconditioned stimulus during the learning. ThisExpand
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Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism
Reversing Autism in Mice Autism comprises a heterogeneous group of neurodevelopmental disorders characterized by defects in communication and social inter action. A group of nonsyndromic forms ofExpand
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Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning
Although feedforward inhibition onto Purkinje cells was first documented 40 years ago, we understand little of how inhibitory interneurons contribute to cerebellar function in behaving animals. UsingExpand
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Calbindin in Cerebellar Purkinje Cells Is a Critical Determinant of the Precision of Motor Coordination
Long-term depression (LTD) of Purkinje cell–parallel fiber synaptic transmission is a critical determinant of normal cerebellar function. Impairment of LTD through, for example, disruption of theExpand
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Cerebellar modules operate at different frequencies
Due to the uniform cyto-architecture of the cerebellar cortex, its overall physiological characteristics have traditionally been considered to be homogeneous. In this study, we show in awake mice atExpand
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