C. D. De Zeeuw

Publications26
h-index4
Citations279
Highly Influential Citations21
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Cerebellar LTD and Pattern Recognition by Purkinje Cells
Summary Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have studied… Expand
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Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning
Summary Closed-loop circuitries between cortical and subcortical regions can facilitate precision of output patterns, but the role of such networks in the cerebellum remains to be elucidated. Here,… Expand
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Role of Synchronous Activation of Cerebellar Purkinje Cell Ensembles in Multi-joint Movement Control
Summary It is a longstanding question in neuroscience how elaborate multi-joint movements are coordinated coherently. Microzones of cerebellar Purkinje cells (PCs) are thought to mediate this… Expand
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AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation
Summary The majority of excitatory postsynaptic currents in the brain are gated through AMPA-type glutamate receptors, the kinetics and trafficking of which can be modulated by auxiliary proteins. It… Expand
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Response to Comment on "Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses"
We disagree with Christian et al . ([ 1 ][1]) regarding the superior sensitivity of electromyogram (EMG) recording. The advantages of magnetic distance measurement technique (MDMT) over EMG… Expand
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The human cerebellum has almost 80% of the surface area of the neocortex
Significance The cerebellum has long been recognized as a partner of the cerebral cortex, and both have expanded greatly in human evolution. The thin cerebellar cortex is even more tightly folded… Expand
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Vector Doppler imaging of small vessels using directionally filtered Power Doppler images
Power Doppler (PD) imaging has become a staple in high frame rate ultrasound imaging due to its ability to image small vessels and slow-moving flows, such as in the case of imaging blood flow in the… Expand
Sleep quality does not mediate the association between chronodisruption and metabolic syndrome
Aims: The objective of the present work was to determine to what extent sleep quality may mediate the association between CD, metabolic syndrome (MS) and body composition (BC). Methodology:… Expand
Pavlovian eyeblink conditioning is severely impaired in tottering mice.
Cacna1a encodes the pore-forming α1A subunit of CaV2.1 voltage-dependent calcium channels, which regulate neuronal excitability and synaptic transmission. Purkinje cells in the cortex of cerebellum… Expand
Complex spike firing adapts to saliency of inputs and engages readiness to act
TLDR
We addressed this hypothesis by recording Purkinje cell activity in lateral cerebellum of awake mice learning go/no-go decisions based on entrained saliency of different sensory stimuli. Expand