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Stability, precision, and near-24-hour period of the human circadian pacemaker.
Regulation of circadian period in humans was thought to differ from that of other species, with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 hours) and the… Expand
Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression.
- J. Zeitzer, D. Dijk, R. Kronauer, E. Brown, C. Czeisler
- Medicine, Chemistry
- The Journal of physiology
- 1 August 2000
Ocular exposure to early morning room light can significantly advance the timing of the human circadian pacemaker. The resetting response to such light has a non-linear relationship to illuminance.… Expand
Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans
The role of the endogenous circadian pacemaker in the timing of the sleep-wake cycle and the regulation of the internal structure of sleep, including REM sleep, EEG slow-wave (0.75–4.5 Hz) and sleep… Expand
The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care*
Objective:Critically ill patients require high-intensity care and may be at especially high risk of iatrogenic injury because they are severely ill. We sought to study the incidence and nature of… Expand
A phase response curve to single bright light pulses in human subjects.
- S. Khalsa, M. Jewett, C. Cajochen, C. Czeisler
- Chemistry, Medicine
- The Journal of physiology
- 1 June 2003
The circadian pacemaker is differentially sensitive to the resetting effects of retinal light exposure, depending upon the circadian phase at which the light exposure occurs. Previously reported… Expand
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
- S. Lockley, Erin E. Evans, F. Scheer, G. Brainard, C. Czeisler, D. Aeschbach
- Medicine, Psychology
- 1 February 2006
STUDY OBJECTIVES To assess the wavelength-dependent sensitivity of the acute effects of ocular light exposure on alertness, performance, waking electroencephalogram (EEG), and cortisol. DESIGN A… Expand
Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness
- C. Cajochen, J. Zeitzer, C. Czeisler, D. Dijk
- Psychology, Medicine
- Behavioural Brain Research
- 1 October 2000
Light can elicit both circadian and acute physiological responses in humans. In a dose response protocol men and women were exposed to illuminances ranging from 3 to 9100 lux for 6.5 h during the… Expand
Measuring and using light in the melanopsin age
Light is a potent stimulus for regulating circadian, hormonal, and behavioral systems. In addition, light therapy is effective for certain affective disorders, sleep problems, and circadian rhythm… Expand
Effect of reducing interns' work hours on serious medical errors in intensive care units.
- C. Landrigan, J. Rothschild, +8 authors C. Czeisler
- The New England journal of medicine
- 28 October 2004
BACKGROUND Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors. METHODS We conducted a prospective, randomized… Expand
High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light.
- S. Lockley, G. Brainard, C. Czeisler
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 1 September 2003
The endogenous circadian oscillator in mammals, situated in the suprachiasmatic nuclei, receives environmental photic input from specialized subsets of photoreceptive retinal ganglion cells. The… Expand