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Lipopolysaccharides from Distinct Pathogens Induce Different Classes of Immune Responses In Vivo1
The adaptive immune system has evolved distinct responses against different pathogens, but the mechanism(s) by which a particular response is initiated is poorly understood. In this study, weExpand
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Oral Mucosal Endotoxin Tolerance Induction in Chronic Periodontitis
ABSTRACT The oral mucosa is exposed to a high density and diversity of gram-positive and gram-negative bacteria, but very little is known about how immune homeostasis is maintained in thisExpand
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A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis.
We describe here the development of a mouse subcutaneous chamber model that allows for the examination of host-parasite interactions as well as the determination of gross pathology with PorphyromonasExpand
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Pathophysiological relationships between periodontitis and systemic disease: recent concepts involving serum lipids.
Periodontitis has been traditionally regarded as a chronic inflammatory oral infection. However, recent studies indicate that this oral disease may have profound effects on systemic health. TheExpand
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Dendritic Cells at the Oral Mucosal Interface
The mucosal lining of the respiratory and digestive systems contains the largest and most complex immune system in the body, but surprisingly little is known of the immune system that serves the oralExpand
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Microorganisms as risk indicators for periodontal disease.
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Mature Dendritic Cells Infiltrate the T Cell-Rich Region of Oral Mucosa in Chronic Periodontitis: In Situ, In Vivo, and In Vitro Studies1
Previous studies have analyzed the lymphoid and myeloid foci within the gingival mucosa in health and chronic periodontitis (CP); however, the principal APCs responsible for the formation andExpand
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  • Open Access
Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of
Phenytoin (pht) is an anticonvulsant drug commonly used for the prevention of seizures. A common side effect of PHT therapy is gingival hyperplasia, occasionally so severe that it requires surgicalExpand
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MMP-9/TIMP-1 imbalance induced in human dendritic cells by Porphyromonas gingivalis.
Matrix metalloproteinase-9 (MMP-9) cleaves collagen, allowing leukocytes to traffic toward the vasculature and the lymphatics. When MMP-9 is unregulated by tissue inhibitor of metalloproteinase-1Expand
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