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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integratedExpand
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The clonal and mutational evolution spectrum of primary triple-negative breast cancers
Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breastExpand
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Comprehensive molecular characterization of gastric adenocarcinoma
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe aExpand
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A Big Bang model of human colorectal tumor growth
What happens in early, still undetectable human malignancies is unknown because direct observations are impractical. Here we present and validate a 'Big Bang' model, whereby tumors grow predominantlyExpand
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The shaping and functional consequences of the microRNA landscape in breast cancer
MicroRNAs (miRNAs) show differential expression across breast cancer subtypes, and have both oncogenic and tumour-suppressive roles. Here we report the miRNA expression profiles of 1,302 breastExpand
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Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling
Image analysis of breast cancer tissue improves and complements genomic data to predict patient survival. Digitizing Pathology for Genomics The tumor microenvironment is a complex milieu thatExpand
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Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity.
Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we explored inter-relationships between putativeExpand
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The chromatin accessibility landscape of primary human cancers
Cancer chromatin accessibility landscape The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al. used a recently modifiedExpand
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Collegiate rugby union injury patterns in New England: a prospective cohort study
Objective: To establish injury profile of collegiate rugby union in the USA Design/setting: 31 men’s and 38 women’s collegiate rugby union teams prospectively recorded injuries during games andExpand
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ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium
The telomeric amplicon at 8p12 is common in oestrogen receptor‐positive (ER+) breast cancers. Array‐CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single geneExpand
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