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Carbazole alkaloids as new cell cycle inhibitor and apopTosis inducers from Clausena dunniana Levl
TLDR
Compounds 1 - 5 provided the first examples of carbazole alkaloids as new cell cycle inhibitors and apoptosis inducers and were identified by spectroscopic methods.
Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L.
TLDR
Labdane-type diterpenes, 1–5, are provided as a new class of cell cycle inhibitors and compounds 1, 2, 4, and 5 as new apoptosis inducers, which also explains, for the first time, the usage of Vitex trifolia L. by Chinese people to treat cancers.
Dihydrotrichodimerol and Tetrahydrotrichodimerol, Two New Bisorbicillinoids, from a Marine-derived Penicillium terrestre
TLDR
Two new bisorbicillinoids possessing an open-ended cage structure, dihydrotrichodimerol and tetrahydrotrimol, were isolated from a marine-derived Penicillium terrestre and their cytotoxic activities against P388 and A-549 cell lines were preliminarily evaluated by the MTT method.
Rare Chromones from a Fungal Mutant of the Marine-Derived Penicillium purpurogenum G59
TLDR
The present work explored the great potential of the previous DES mutagenesis strategy for activating silent fungal pathways, which has accelerated the discovery of new bioactive compounds.
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties.
TLDR
The diketopiperazines showed an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase with the MIC values of 16.4 microM and 12.2 microM, respectively.
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures.
TLDR
The structures of tryprostatins A, B and demethoxyfumitremorgin C were determined mainly by the use of spectroscopic methods especially by detailed analyses of their 1H and 13C NMR spectra with the aid of 2D NMR techniques including pulse field gradient heteronuclear multiple-bond correlation (PFG-HMBC) spectroscopy.
10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans.
TLDR
The three new 10-phenyl-[12]-cytochalasins Z7, Z8, and Z9 (1-3), together with two known analogues, cytochal asins E (4) and K (5), were isolated from the marine-derived fungus Spicaria elegans and found to contain a 12-membered macrocyclic ring.
Pterocarine, a New Diarylheptanoid from Pterocarya tonkinesis, Its Cell Cycle Inhibition at G0/G1 Phase and Induction of Apoptosis in HCT-15 and K562 Cells
TLDR
Flow cytometric analysis indicated that Pterocarine could inhibit the cell cycle of tsFT210, HCT-15 and K562 cells at the G0/G1 phase and could also induce apoptosis in H CT-15 (19%) and K552 (11%) cells.
Potentin Vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomyceteSac-charopolyspora sp. nov.
TLDR
These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4.
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